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J. Funct. Biomater. 2016, 7(4), 34; doi:10.3390/jfb7040034

Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection

1
Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
2
Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
3
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
4
McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15213, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Daniel X.B. Chen
Received: 31 October 2016 / Revised: 5 December 2016 / Accepted: 9 December 2016 / Published: 13 December 2016
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Abstract

Stenting is an alternative to endarterectomy for the treatment of carotid artery stenosis. However, stenting is associated with a higher risk of procedural stroke secondary to distal thromboembolism. Hybrid stents with a micromesh layer have been proposed to address this complication. We developed a micropatterned thin film nitinol (M-TFN) covered stent designed to prevent thromboembolism during carotid intervention. This innovation may obviate the need or work synergistically with embolic protection devices. The proposed double layered stent is low-profile, thromboresistant, and covered with a M-TFN that can be fabricated with fenestrations of varying geometries and sizes. The M-TFN was created in multiple geometries, dimensions, and porosities by sputter deposition. The efficiency of various M-TFN to capture embolic particles was evaluated in different atherosclerotic carotid stenotic conditions through in vitro tests. The covered stent prevented emboli dislodgement in the range of 70%–96% during 30 min duration tests. In vitro vascular cell growth study results showed that endothelial cell elongation, alignment and growth behaviour silhouettes significantly enhance, specifically on the diamond-shape M-TFN, with the dimensions of 145 µm × 20 µm and a porosity of 32%. Future studies will require in vivo testing. Our results demonstrate that M-TFN has a promising potential for carotid artery stenting. View Full-Text
Keywords: thin film nitinol; carotid artery; micro mesh stent; micropatterning thin film nitinol; carotid artery; micro mesh stent; micropatterning
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MDPI and ACS Style

Shayan, M.; Jankowitz, B.T.; Shridhar, P.; Chun, Y. Use of Micropatterned Thin Film Nitinol in Carotid Stents to Augment Embolic Protection. J. Funct. Biomater. 2016, 7, 34.

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