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J. Funct. Biomater. 2016, 7(4), 29; doi:10.3390/jfb7040029

Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran

1
NeuroTrauma Department, Naval Medical Research Center (NMRC), Silver Spring, MD 20910, USA
2
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD 20895, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Pankaj Vadgama
Received: 16 September 2016 / Revised: 9 November 2016 / Accepted: 11 November 2016 / Published: 18 November 2016
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Abstract

Oxygen-carrying perfluorocarbon (PFC) fluids have the potential to increase tissue oxygenation during hypoxic states and to reduce ischemic cell death. Regulatory approval of oxygen therapeutics was halted due to concerns over vasoconstrictive side effects. The goal of this study was to assess the potential vasoactive properties of Perftoran by measuring brain pial arteriolar diameters in a healthy rat model. Perftoran, crystalloid (saline) or colloid (Hextend) solutions were administered as four sequential 30 min intravenous (IV) infusions, thus allowing an evaluation of cumulative dose-dependent effects. There were no overall changes in diameters of small-sized (<50 μm) pial arterioles within the Perftoran group, while both saline and Hextend groups exhibited vasoconstriction. Medium-sized arterioles (50–100 μm) showed minor (~8–9%) vasoconstriction within saline and Hextend groups and only ~5% vasoconstriction within the Perftoran group. For small- and medium-sized pial arterioles, the mean percent change in vessel diameters was not different among the groups. Although there was a tendency for arterial blood pressures to increase with Perftoran, pressures were not different from the other two groups. These data show that Perftoran, when administered to healthy anesthetized rats, does not cause additional vasoconstriction in cerebral pial arterioles or increase systemic blood pressure compared with saline or Hextend. View Full-Text
Keywords: cerebral microcirculation; perfluorocarbon (PFC); oxygen therapeutic; vasoconstriction; intravital microscopy cerebral microcirculation; perfluorocarbon (PFC); oxygen therapeutic; vasoconstriction; intravital microscopy
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MDPI and ACS Style

Abutarboush, R.; Saha, B.K.; Mullah, S.H.; Arnaud, F.G.; Haque, A.; Aligbe, C.; Pappas, G.; Auker, C.R.; McCarron, R.M.; Moon-Massat, P.F.; Scultetus, A.H. Cerebral Microvascular and Systemic Effects Following Intravenous Administration of the Perfluorocarbon Emulsion Perftoran. J. Funct. Biomater. 2016, 7, 29.

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J. Funct. Biomater. EISSN 2079-4983 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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