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J. Funct. Biomater. 2015, 6(3), 963-985; doi:10.3390/jfb6030963

A Closer Look at Schlemm’s Canal Cell Physiology: Implications for Biomimetics

State University of New York (SUNY) Polytechnic Institute, Colleges of Nanoscale Science and Engineering, 257 Fuller Road, Albany, NY 12203, USA
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Author to whom correspondence should be addressed.
Academic Editor: Dimitrios Karamichos
Received: 30 June 2015 / Revised: 10 August 2015 / Accepted: 6 September 2015 / Published: 21 September 2015
(This article belongs to the Special Issue Ocular Tissue Engineering)
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Abstract

Among ocular pathologies, glaucoma is the second leading cause of progressive vision loss, expected to affect 80 million people worldwide by 2020. A primary cause of glaucoma appears to be damage to the conventional outflow tract. Conventional outflow tissues, a composite of the trabecular meshwork and the Schlemm’s canal, regulate and maintain homeostatic responses to intraocular pressure. In glaucoma, filtration of aqueous humor into the Schlemm’s canal is hindered, leading to an increase in intraocular pressure and subsequent damage to the optic nerve, with progressive vision loss. The Schlemm’s canal encompasses a unique endothelium. Recent advances in culturing and manipulating Schlemm’s canal cells have elucidated several aspects of their physiology, including ultrastructure, cell-specific marker expression, and biomechanical properties. This review highlights these advances and discusses implications for engineering a 3D, biomimetic, in vitro model of the Schlemm’s canal endothelium to further advance glaucoma research, including drug testing and gene therapy screening. View Full-Text
Keywords: Schlemm’s canal; conventional outflow tract; intraocular pressure; glaucoma; biomimetics; tissue engineering; nanofabrication Schlemm’s canal; conventional outflow tract; intraocular pressure; glaucoma; biomimetics; tissue engineering; nanofabrication
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Dautriche, C.N.; Tian, Y.; Xie, Y.; Sharfstein, S.T. A Closer Look at Schlemm’s Canal Cell Physiology: Implications for Biomimetics. J. Funct. Biomater. 2015, 6, 963-985.

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