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Computation 2015, 3(2), 114-127; doi:10.3390/computation3020114

Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing Genes

Department of Biology, National University of Ireland Maynooth, Co. Kildare, Ireland
These authors contributed equally to this work.
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Academic Editors: Rainer Breitling and Marnix Medema
Received: 8 September 2014 / Revised: 10 March 2015 / Accepted: 11 March 2015 / Published: 26 March 2015
(This article belongs to the Special Issue Genomes and Evolution: Computational Approaches)
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Abstract

Phylogenetic (tree-based) approaches to understanding evolutionary history are unable to incorporate convergent evolutionary events where two genes merge into one. In this study, as exemplars of what can be achieved when a tree is not assumed a priori, we have analysed the evolutionary histories of polyketide synthase genes and antibiotic resistance genes and have shown that their history is replete with convergent events as well as divergent events. We demonstrate that the overall histories of these genes more closely resembles the remodelling that might be seen with the children’s toy Lego, than the standard model of the phylogenetic tree. This work demonstrates further that genes can act as public goods, available for re-use and incorporation into other genetic goods. View Full-Text
Keywords: polyketide; network; homology; evolution; phylogeny; connected component; community structure polyketide; network; homology; evolution; phylogeny; connected component; community structure
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Coleman, O.; Hogan, R.; McGoldrick, N.; Rudden, N.; McInerney, J.O. Evolution by Pervasive Gene Fusion in Antibiotic Resistance and Antibiotic Synthesizing Genes. Computation 2015, 3, 114-127.

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