Exploratory Study on Visual Acuity and Patient-Perceived Visual Function in Patients with Subretinal Drusenoid Deposits
Abstract
:1. Introduction
2. Experimental Section
2.1. Participants
- (1)
- No AMD or presence of druplets
- (2)
- Intermediate AMD with no SDD (iAMD with no SDD)
- (3)
- Intermediate AMD with at least 5 SDD (SDD group)
- (4)
- Non-foveal atrophic AMD with intermediate AMD
2.1.1. Exclusion Criteria
2.1.2. Visual Function Tests
2.1.3. Subjective Test
2.1.4. Statistical Analysis
3. Results
3.1. Demographic and Clinical Characteristics of the Participants
3.2. Age-Related Decline in Visual Function
3.3. Visual Acuity Assessments
3.4. Subjective Assessment
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Group, Mean ± SD, Median (Minimum, Maximum) | Pairwise Comparisons Post Hoc Uncorrected Dunn’s Test p Value | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Test | Healthy Aging (n = 11) | iAMD No SDD (n = 17) | iAMD with SDD (n = 11) | Non-Foveal Atrophic AMD (n = 10) † | Overall p Value * | Healthy Aging vs. iAMD No SDD | Healthy Aging vs. iAMD with SDD | Healthy Aging vs. Non-Foveal Atrophic AMD | iAMD No SDD vs. iAMD with SDD | iAMD No SDD vs. Non-Foveal Atrophic AMD | iAMD with SDD vs. Non-Foveal Atrophic AMD |
BCVA (letters) | 87.6 (±4.8) | 85.7 (±6.1) | 83.6 (±4.3) | 74.2 (±11.2) | 0.0005 | 0.237 | 0.028 | <0.0001 | 0.218 | 0.001 | 0.065 |
78, 89, 93 | 67, 87, 93 | 77, 83, 90 | 50, 76.5, 87 | ||||||||
LLVA (letters) | 74.1 (±3.89) | 71.1 (±8.2) | 67.3 (±8.2) | 60.8 (±12.1) | 0.0077 | 0.385 | 0.045 | 0.0016 | 0.181 | 0.009 | 0.230 |
68, 75, 82 | 47, 73, 80 | 56, 67, 79 | 40, 64.5, 74 | ||||||||
LLD (letters) | 13.5 (±2.3) | 14.6 (±4.3) | 16.3 (±4.6) | 13.4 (±3.7) | 0.4244 | - | - | - | - | - | - |
10, 14, 17 | 9, 14, 22 | 11, 15, 26 | 9, 12.5, 20 |
Group, Mean ± SD, Median (Minimum, Maximum) | Pairwise Comparisons Post Hoc Uncorrected Dunn’s Test p Value † | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
LLQ Categories | Healthy Aging (n = 11) | iAMD No SDD (n = 17) | iAMD with SDD (n = 11) | Atrophic AMD (n = 11) | Overall p-Value * | Healthy Aging vs. iAMD No SDD | Healthy Aging vs. iAMD with SDD | Healthy Aging vs. Non-Foveal Atrophic AMD | iAMD No SDD vs. iAMD with SDD | iAMD No SDD vs. Non-Foveal Atrophic AMD | iAMD with SDD vs. Non-Foveal Atrophic AMD |
Extreme lighting | 90.5 ± 9.0, 93.8 | 77.5 ± 13.1, 75.0 | 81.3 ± 15.4, 78.1 | 61.8 ± 26.9, 68.8 | 0.015 | 0.030 | 0.210 | 0.0017 | 0.432 | 0.197 | 0.060 |
(78.1, 100.0) | (53.1, 100.0) | (53.1, 100.0) | (21.9, 95.8) | ||||||||
Mobility | 97.0 ± 4.6, 100.0 | 93.6 ± 7.1, 95.8 | 92.4 ± 10.7, 100.0 | 86.0 ± 18.0, 91.7 | 0.451 | - | - | - | - | - | - |
(87.5, 100.0) | (79.2, 100.0) | (75.0, 100.0) | (45.8, 100.0) | ||||||||
General dim lighting | 95.5 ± 6.6, 100.0 | 89.5 ± 10.7, 91.7 | 93.2 ± 9.9, 100.0 | 76.1 ± 23.0, 79.2 | 0.051 | - | - | - | - | - | - |
(83.3, 100.0) | (66.7, 100.0) | (75.0, 100.0) | (41.7, 100.0) | ||||||||
Peripheral vision | 96.2 ± 8.6, 100.0 | 94.1 ± 8.7, 100.0 | 96.2 ± 8.6, 100.0 | 80.3 ± 26.7, 91.7 | 0.092 | - | - | - | - | - | - |
(75.0, 100.0) | (75.0, 100.0) | (75.0. 100.0) | (25.0, 100.0) | ||||||||
Driving | 93.0 ± 10.3, 95.0 | 83.5 ± 17.0, 90.0 | 79.5 ± 29.7, 90.0 | 58.6 ± 36.5, 50.0 | 0.157 | - | - | - | - | - | - |
(65.0, 100.0) | (45.0, 100.0) | (5.0, 100.0) | (0.0, 100.0) | ||||||||
Emotional distress | 100.0 ± 0.0, 100.0 | 92.7 ± 10.4, 100.0 | 91.5 ± 15.4, 100.0 | 75.6 ± 29.5, 93.8 | 0.032 | 0.047 | 0.100 | 0.0034 | 0.861 | 0.216 | 0.200 |
(100.0, 100.0) | (68.8, 100.0) | (50.0, 100.0) | (25.0, 100.0) | ||||||||
Composite | 94.8 ± 5.2, 96.1 | 87.3 ± 9.1, 90.6 | 87.7 ± 12.9, 93.8 | 72.8 ± 24.6, 71.1 | 0.032 | 0.044 | 0.203 | 0.0038 | 0.543 | 0.240 | 0.106 |
(83.6, 100.0) | (71.9, 99.2) | (66.4, 100.0) | (27.3, 98.0) |
Outcome Measure | Healthy Aging | AMD No SDD | AMD with SDD | Non-Foveal Atrophic AMD | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
B Coefficient | Standardized Coefficient | p Value | B Coefficient | Standardized Coefficient | p Value | B Coefficient | Standardized Coefficient | p Value | B Coefficient | Standardized Coefficient | p Value | |
BCVA | −0.299 | −0.276 | 0.411 | 0.551 | 0.368 | 0.146 | 1.828 | 0.608 | 0.047 | 0.076 | 0.041 | 0.910 |
LLVA | −0.203 | −0.153 | 0.654 | 0.186 | 0.166 | 0.523 | 0.927 | 0.592 | 0.055 | 0.239 | 0.141 | 0.697 |
LLD | −0.734 | −0.321 | 0.337 | 0.444 | 0.208 | 0.424 | −1.359 | −0.489 | 0.127 | −1.859 | −0.337 | 0.341 |
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Grewal, M.K.; Chandra, S.; Gurudas, S.; Bird, A.; Jeffery, G.; Sivaprasad, S. Exploratory Study on Visual Acuity and Patient-Perceived Visual Function in Patients with Subretinal Drusenoid Deposits. J. Clin. Med. 2020, 9, 2832. https://doi.org/10.3390/jcm9092832
Grewal MK, Chandra S, Gurudas S, Bird A, Jeffery G, Sivaprasad S. Exploratory Study on Visual Acuity and Patient-Perceived Visual Function in Patients with Subretinal Drusenoid Deposits. Journal of Clinical Medicine. 2020; 9(9):2832. https://doi.org/10.3390/jcm9092832
Chicago/Turabian StyleGrewal, Manjot K., Shruti Chandra, Sarega Gurudas, Alan Bird, Glen Jeffery, and Sobha Sivaprasad. 2020. "Exploratory Study on Visual Acuity and Patient-Perceived Visual Function in Patients with Subretinal Drusenoid Deposits" Journal of Clinical Medicine 9, no. 9: 2832. https://doi.org/10.3390/jcm9092832