Serum Levels of Angiopoietin-Like Protein 2 and Obestatin in Iranian Women with Polycystic Ovary Syndrome and Normal Body Mass Index
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Design
2.2. Inclusion and Exclusion Criteria
2.3. Sampling and Measurement of Parameters
2.4. Ethical Consideration
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Characteristic | Control Group | Case Group | p Value |
---|---|---|---|
Age (years) | 28.91 ± 8.1 | 25.85 ± 5.90 | 0.12 |
Weight (kg) | 62.47 ± 15.18 | 66.74 ± 12.41 | 0.28 |
Height (cm) | 161.17 ± 4.71 | 159.52 ± 6.37 | 0.3 |
BMI (kg/m2) | 24.02 ± 5.60 | 24.91± 3.63 | 0.4 |
WHR | 0.8 ± 0.07 | 0.82 ± 0.06 | 0.27 |
Characteristic | Control Group | Case Group | p Value |
---|---|---|---|
Obestatin (ng/mL) | 16.55 ± 10.07 | 17.72 ± 10.56 | 0.69 |
ANGPTL2 (ng/mL) | 143.69 ± 125.79 | 144.52 ± 131.84 | 0.98 |
Insulin (μIU/mL) | 8.76 ± 6.63 | 16.42 ± 10.01 | 0.04 |
HOMA-IR | 2.06 ± 2.04 | 4.11 ± 3.29 | 0.04 |
FBS (mg/dL) | 91.29 ± 8.53 | 98.71 ± 11.44 | 0.01 |
Triglyceride (mg/dL) | 86.79 ± 50.23 | 107.04 ± 45.03 | 0.13 |
Cholesterol (mg/dL) | 167.83 ± 29.18 | 175.07 ± 23.32 | 0.3 |
HDL-C (mg/dL) | 49.25 ± 12.59 | 47.92 ± 10.08 | 0.67 |
LDL-C (mg/dL) | 100.96 ± 26.55 | 99.60 ± 25.72 | 0.62 |
LH (mIu/mL) | 5.54 ± 2.84 | 9.46 ± 5.6 | 0.004 |
FSH (mIu/mL) | 6.28 ± 2.13 | 5.24 ± 2.35 | 0.1 |
LH/FSH | 1.06 ± 0.84 | 2.27 ± 1.92 | 0.006 |
Testosterone (ng/mL) | 0.71 ± 0.26 | 0.99 ± 0.52 | 0.02 |
DHEAS (µg/dL) | 1.83 ± 0.78 | 1.99 ± 0.87 | 0.4 |
Prolactin (ng/mL) | 15.00 ± 8.84 | 21.23 ± 11.94 | 0.04 |
Cr (mg/dL) | 0.80 ± 0.16 | 0.81 ± 0.13 | 0.7 |
Correlation | BMI | Insulin | HOMA.IR | ||
---|---|---|---|---|---|
Case group | ANGPTL2 (ng/mL) | Pearson correlation | 0.03 | 0.45 | 0.46 |
p-value | 0.86 | 0.02 | 0.01 | ||
Obestatin (ng/mL) | Pearson correlation | −0.07 | −0.49 | −0.51 | |
p-value | 0.74 | 0.01 | 0.008 | ||
Control group | ANGPTL2 (ng/mL) | Pearson correlation | 0.37 | 0.39 | 0.40 |
p-value | 0.06 | 0.04 | 0.04 | ||
Obestatin (ng/mL) | Pearson correlation | −0.30 | −0.42 | −0.39 | |
p-value | 0.08 | 0.03 | 0.04 |
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Rahmani, E.; Akbarzadeh, S.; Broomand, A.; Torabi, F.; Motamed, N.; Zohrabi, M. Serum Levels of Angiopoietin-Like Protein 2 and Obestatin in Iranian Women with Polycystic Ovary Syndrome and Normal Body Mass Index. J. Clin. Med. 2018, 7, 159. https://doi.org/10.3390/jcm7070159
Rahmani E, Akbarzadeh S, Broomand A, Torabi F, Motamed N, Zohrabi M. Serum Levels of Angiopoietin-Like Protein 2 and Obestatin in Iranian Women with Polycystic Ovary Syndrome and Normal Body Mass Index. Journal of Clinical Medicine. 2018; 7(7):159. https://doi.org/10.3390/jcm7070159
Chicago/Turabian StyleRahmani, Elham, Samad Akbarzadeh, Ainaz Broomand, Fatemeh Torabi, Niloofar Motamed, and Marzieh Zohrabi. 2018. "Serum Levels of Angiopoietin-Like Protein 2 and Obestatin in Iranian Women with Polycystic Ovary Syndrome and Normal Body Mass Index" Journal of Clinical Medicine 7, no. 7: 159. https://doi.org/10.3390/jcm7070159