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J. Clin. Med. 2017, 6(4), 41; doi:10.3390/jcm6040041

Natural Killer T Cells in Liver Ischemia–Reperfusion Injury

1
Department of Surgery, Division of Transplant Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA
2
Histocompatibility and Immunogenetics, Blood Center of Wisconsin, Milwaukee, WI 53201, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Dimitris E. Giakoustidis
Received: 9 February 2017 / Revised: 10 March 2017 / Accepted: 20 March 2017 / Published: 1 April 2017
View Full-Text   |   Download PDF [206 KB, uploaded 1 April 2017]

Abstract

Restoration of blood flow to an ischemic organ results in significant tissue injury. In the field of liver transplantation, ischemia–reperfusion injury (IRI) has proven to be a formidable clinical obstacle. In addition to metabolic stress and inflammation, IRI results in profound graft dysfunction and loss. The severity of IRI further limits the ability to expand the donor pool by using partial grafts and marginal organs. As such, the inflammatory response to reperfusion of the liver continues to be an area of intense investigation. Among the various leukocytes involved in IRI, new insights suggest that natural killer T (NKT) cells may be a central driver of hepatocellular injury. Herein, we examine recent experimental observations that provide a mechanistic link between NKT cell recruitment to liver and post-perfusion tissue injury. View Full-Text
Keywords: lymphocyte; liver; ischemia; reperfusion; transplant lymphocyte; liver; ischemia; reperfusion; transplant
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zimmerman, M.A.; Martin, A.; Yee, J.; Schiller, J.; Hong, J.C. Natural Killer T Cells in Liver Ischemia–Reperfusion Injury. J. Clin. Med. 2017, 6, 41.

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