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J. Clin. Med. 2016, 5(6), 55; doi:10.3390/jcm5060055

A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?

1
The Gut Health and Food Safety Research Programme, The Institute of Food Research, University of East Anglia, Norwich NR4 7UA, UK
2
Norwich Medical School, University of East Anglia, Norwich NR4 7TJ, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Luis Vitetta
Received: 18 April 2016 / Revised: 23 May 2016 / Accepted: 31 May 2016 / Published: 6 June 2016
(This article belongs to the Special Issue Advances in Human Microbiome)
View Full-Text   |   Download PDF [278 KB, uploaded 6 June 2016]

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a heterogeneous disorder of significant societal impact that is proposed to involve both host and environmentally derived aetiologies that may be autoimmune in nature. Immune-related symptoms of at least moderate severity persisting for prolonged periods of time are common in ME/CFS patients and B cell depletion therapy is of significant therapeutic benefit. The origin of these symptoms and whether it is infectious or inflammatory in nature is not clear, with seeking evidence of acute or chronic virus infections contributing to the induction of autoimmune processes in ME/CFS being an area of recent interest. This article provides a comprehensive review of the current evidence supporting an infectious aetiology for ME/CFS leading us to propose the novel concept that the intestinal microbiota and in particular members of the virome are a source of the “infectious” trigger of the disease. Such an approach has the potential to identify disease biomarkers and influence therapeutics, providing much-needed approaches in preventing and managing a disease desperately in need of confronting. View Full-Text
Keywords: myalgic encephalomyelitis; chronic fatigue syndrome; intestinal microbiota; dysbiosis; microbiome; virome myalgic encephalomyelitis; chronic fatigue syndrome; intestinal microbiota; dysbiosis; microbiome; virome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Navaneetharaja, N.; Griffiths, V.; Wileman, T.; Carding, S.R. A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)? J. Clin. Med. 2016, 5, 55.

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