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J. Clin. Med. 2016, 5(12), 114; doi:10.3390/jcm5120114

A Review of Targeted Pulmonary Arterial Hypertension-Specific Pharmacotherapy

Pulmonary Hypertension Program, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, 1600 SW Archer Rd, M452, P.O. Box 100225, Gainesville, FL 32610, USA
Author to whom correspondence should be addressed.
Academic Editor: Jane A. Leopold
Received: 9 September 2016 / Revised: 22 November 2016 / Accepted: 29 November 2016 / Published: 6 December 2016
(This article belongs to the Special Issue Novel Therapeutic Approaches for Pulmonary Arterial Hypertension)
View Full-Text   |   Download PDF [226 KB, uploaded 6 December 2016]


Significant advances in the understanding of the pathophysiology of pulmonary arterial hypertension over the past two decades have led to the development of targeted therapies and improved patient outcomes. Currently, a broad armamentarium of pulmonary arterial hypertension-specific drugs exists to assist in the treatment of this complex disease state. In this manuscript, we provide a comprehensive review of the current Food and Drug Administration (FDA)-approved pulmonary arterial hypertension-specific therapies, and their supporting evidence for adults, targeting the nitric oxide, soluble guanylate cyclase, endothelin, and prostacyclin pathways. View Full-Text
Keywords: pulmonary hypertension; pulmonary arterial hypertension; nitric oxide; soluble guanylate cyclase; endothelin; prostacyclin pulmonary hypertension; pulmonary arterial hypertension; nitric oxide; soluble guanylate cyclase; endothelin; prostacyclin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ataya, A.; Cope, J.; Alnuaimat, H. A Review of Targeted Pulmonary Arterial Hypertension-Specific Pharmacotherapy. J. Clin. Med. 2016, 5, 114.

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