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J. Clin. Med. 2015, 4(7), 1403-1427; doi:10.3390/jcm4071403

Diabetic Nephropathy without Diabetes

1
Unidad de Nefrología, Hospital Universitario Fundación Alcorcón, C/ Budapest, 1, 28922 Madrid, Spain
2
Unidad de Anatomía Patológica, Hospital Universitario Fundación Alcorcón, C/ Budapest, 1, 28922 Madrid, Spain
3
Unidad de Investigación, Hospital Universitario Fundación Alcorcón, C/ Budapest, 1, 28922 Madrid, Spain
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Juan F. Navarro-González
Received: 1 April 2015 / Revised: 3 June 2015 / Accepted: 3 June 2015 / Published: 9 July 2015
(This article belongs to the Special Issue Diabetic Nephropathy)
View Full-Text   |   Download PDF [480 KB, uploaded 9 July 2015]   |  

Abstract

Diabetic nephropathy without diabetes (DNND), previously known as idiopathic nodular glomerulosclerosis, is an uncommon entity and thus rarely suspected; diagnosis is histological once diabetes is discarded. In this study we describe two new cases of DNND and review the literature. We analyzed all the individualized data of previous publications except one series of attached data. DNND appears to be favored by recognized cardiovascular risk factors. However, in contrast with diabetes, apparently no factor alone has been demonstrated to be sufficient to develop DNND. Other factors not considered as genetic and environmental factors could play a role or interact. The most plausible hypothesis for the occurrence of DNND would be a special form of atherosclerotic or metabolic glomerulopathy than can occur with or without diabetes. The clinical spectrum of cardiovascular risk factors and histological findings support this theory, with hypertension as one of the characteristic clinical features. View Full-Text
Keywords: diabetic nephropathy; idiopathic nodular glomerulosclerosis; hypertension; insulin resistance diabetic nephropathy; idiopathic nodular glomerulosclerosis; hypertension; insulin resistance
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

López-Revuelta, K.; Abreu, A.A.M.; Gerrero-Márquez, C.; Stanescu, R.-I.; Marín, M.I.M.; Fernández, E.P. Diabetic Nephropathy without Diabetes. J. Clin. Med. 2015, 4, 1403-1427.

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