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J. Clin. Med. 2015, 4(5), 822-831; doi:10.3390/jcm4050822

Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma

1
University of Florida College of Medicine, 1600 SW Archer Rd., Gainesville, FL 32603, USA
2
Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
3
Paul L. Foster School of Medicine, 5001 El Paso Dr., El Paso, TX 79905, USA
4
Department of Dermatology, University of Texas Medical School at Houston, 6655 Travis Street, Houston, TX 77030, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Jane Grant-Kels
Received: 24 October 2014 / Revised: 5 March 2015 / Accepted: 6 March 2015 / Published: 24 April 2015
(This article belongs to the Special Issue Clinical Advances of Human Papillomaviruses)
View Full-Text   |   Download PDF [56 KB, uploaded 24 April 2015]

Abstract

Head and neck carcinomas have long been linked to alcohol and tobacco abuse; however, within the last two decades, the human papillomavirus (HPV) has emerged as a third etiology and is specifically associated with head and neck squamous cell carcinomas (HNSCC). In this anatomical region, the oncogenic HPV-16 mediates transformation and immortalization of epithelium, most commonly in the oropharynx. Nevertheless, the recent identification of novel HPV mechanisms thought to be specific to oropharyngeal carcinogenesis has coincided with observations that HPV-associated HNSCC has differing clinical behavior—in terms of natural history, therapeutic response, and prognosis—than HPV-negative head and neck tumors. Taken together with the growing incidence of HPV transmission in younger populations, these discoveries have sparked a rapid expansion in both laboratory and clinical studies on the infection and disease. Herein, we review the clinical characteristics of HPV-associated HNSCC, with particular emphasis on recent advancements in our understanding of the management of this infectious malignancy. View Full-Text
Keywords: human papillomavirus; head and neck squamous cell carcinoma; oropharyngeal carcinoma; viral carcinogenesis human papillomavirus; head and neck squamous cell carcinoma; oropharyngeal carcinoma; viral carcinogenesis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Zeitlin, R.; Nguyen, H.P.; Rafferty, D.; Tyring, S. Advancements in the Management of HPV-Associated Head and Neck Squamous Cell Carcinoma. J. Clin. Med. 2015, 4, 822-831.

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