Limitations of Aneuploidy and Anomaly Detection in the Obese Patient
AbstractObesity is a worldwide epidemic and can have a profound effect on pregnancy risks. Obese patients tend to be older and are at increased risk for structural fetal anomalies and aneuploidy, making screening options critically important for these women. Failure rates for first-trimester nuchal translucency (NT) screening increase with obesity, while the ability to detect soft-markers declines, limiting ultrasound-based screening options. Obesity also decreases the chances of completing the anatomy survey and increases the residual risk of undetected anomalies. Additionally, non-invasive prenatal testing (NIPT) is less likely to provide an informative result in obese patients. Understanding the limitations and diagnostic accuracy of aneuploidy and anomaly screening in obese patients can help guide clinicians in counseling patients on the screening options. View Full-Text
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Zozzaro-Smith, P.; Gray, L.M.; Bacak, S.J.; Thornburg, L.L. Limitations of Aneuploidy and Anomaly Detection in the Obese Patient. J. Clin. Med. 2014, 3, 795-808.
Zozzaro-Smith P, Gray LM, Bacak SJ, Thornburg LL. Limitations of Aneuploidy and Anomaly Detection in the Obese Patient. Journal of Clinical Medicine. 2014; 3(3):795-808.Chicago/Turabian Style
Zozzaro-Smith, Paula; Gray, Lisa M.; Bacak, Stephen J.; Thornburg, Loralei L. 2014. "Limitations of Aneuploidy and Anomaly Detection in the Obese Patient." J. Clin. Med. 3, no. 3: 795-808.