Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold
Abstract
:1. Introduction
2. Case Presentation and Discussion
2.1. Case 1
2.2. Case 2
2.3. Case 3
3. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
- Nickell, L.T., Jr.; Lichtenberger, J.P., 3rd; Khorashadi, L.; Abbott, G.F.; Carter, B.W. Multimodality imaging for characterization, classification, and staging of malignant pleural mesothelioma. Radiographics 2014, 34, 1692–1706. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Scherpereel, A.; Opitz, I.; Berghmans, T.; Psallidas, I.; Glatzer, M.; Rigau, D.; Astoul, P.; Bölükbas, S.; Boyd, J.; Coolen, J.; et al. ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma. Eur. Respir. J. 2020, 55, 1900953. [Google Scholar] [CrossRef]
- Binazzi, A.; Di Marzio, D.; Verardo, M.; Migliore, E.; Benfatto, L.; Malacarne, D.; Mensi, C.; Consonni, D.; Eccher, S.; Mazzoleni, G.; et al. Asbestos exposure and malignant mesothelioma in construction workers—Epidemiological remarks by the Italian National Mesothelioma Registry (Renam). Int. J. Environ. Res. Public Health 2021, 19, 235. [Google Scholar] [CrossRef]
- Peto, J.; Decarli, A.; La Vecchia, C.; Levi, F.; Negri, E. The European mesothelioma epidemic. Br. J. Cancer 1999, 79, 666–672. [Google Scholar] [CrossRef] [Green Version]
- Cavone, D.; Caputi, A.; De Maria, L.; Cannone, E.S.S.; Mansi, F.; Birtolo, F.; Delfino, M.C.; Vimercati, L. Epidemiology of Mesothelioma. Environments 2019, 6, 76. [Google Scholar] [CrossRef] [Green Version]
- Galateau-Salle, F.; Churg, A.; Roggli, V.; Travis, W.D.; World Health Organization Committee for Tumors of the Pleura. The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification. J. Thorac. Oncol. 2016, 11, 142–154. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Nicholson, A.G.; Sauter, J.L.; Nowak, A.K.; Kindler, H.L.; Gill, R.R.; Remy-Jardin, M.; Armato, S.G., III; Fernandez-Cuesta, L.; Bueno, R.; Alcala, N.; et al. EURACAN/IASLC proposals for updating the histologic classification of pleural mesothelioma: Towards a more multidisciplinary approach. J. Thorac. Oncol. 2020, 15, 29–49. [Google Scholar] [CrossRef]
- Carbone, M.; Adusumilli, P.S.; Alexander, H.R., Jr.; Baas, P.; Bardelli, F.; Bononi, A.; Bueno, R.; Felley-Bosco, E.; Galateau-Salle, F.; Jablons, D.; et al. Mesothelioma: Scientific clues for prevention, diagnosis, and therapy. CA Cancer J. Clin. 2019, 69, 402–429. [Google Scholar] [CrossRef] [Green Version]
- Reck, M.; Ciuleanu, T.E.; Lee, J.S.; Schenker, M.; Audigier-Valette, C.; Zurawski, B.; Linardou, H.; Otterson, G.A.; Salman, P.; Nishio, M.; et al. First-line nivolumab plus ipilimumab versus chemotherapy in patients with unresectable malignant pleural mesothelioma: 3-year outcomes from CheckMate 743. Ann. Oncol. 2022, S0923-7534, 83–87. [Google Scholar]
- Bibby, A.C.; Tsim, S.; Kanellakis, N.; Ball, H.; Talbot, D.C.; Blyth, K.G.; Maskell, N.A.; Psallidas, I. Malignant pleural mesothelioma: An update on investigation, diagnosis and treatment. Eur. Respir. Rev. 2016, 25, 472–486. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Rossi, G.; Davoli, F.; Poletti, V.; Cavazza, A.; Lococo, F. When the Diagnosis of Mesothelioma Challenges Textbooks and Guidelines. J. Clin. Med. 2021, 10, 2434. [Google Scholar] [CrossRef]
- Henderson, D.W.; Reid, G.; Kao, S.C.; van Zandwijk, N.; Klebe, S. Challenges and controversies in the diagnosis of mesothelioma: Part 1. Cytology-only diagnosis, biopsies, immunohistochemistry, discrimination between mesothelioma and reactive mesothelial hyperplasia, and biomarkers. J. Clin. Pathol. 2013, 66, 847–853. [Google Scholar] [CrossRef]
- Husain, A.N.; Colby, T.V.; Ordóñez, N.G.; Allen, T.C.; Attanoos, R.L.; Beasley, M.B.; Butnor, K.J.; Chirieac, L.R.; Churg, A.M.; Dacic, S.; et al. Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement from the International Mesothelioma Interest Group. Arch. Pathol. Lab. Med. 2018, 142, 89–108. [Google Scholar] [CrossRef] [Green Version]
- Bernardi, L.; Bizzarro, T.; Pironi, F.; Szymczuk, S.; Buda, R.; Fabbri, E.; Di Claudio, G.; Rossi, G. The “Brescia panel” (Claudin-4 and BRCA-associated protein 1) in the differential diagnosis of mesotheliomas with epithelioid features versus metastatic carcinomas. Cancer Cytopathol. 2021, 129, 275–282. [Google Scholar] [CrossRef]
- Churg, A.; Attanoos, R.; Borczuk, A.C.; Chirieac, L.R.; Galateau-Sallé, F.; Gibbs, A.; Henderson, D.; Roggli, V.; Rusch, V.; Judge, M.J.; et al. Dataset for Reporting of Malignant Mesothelioma of the Pleura or Peritoneum: Recommendations from the International Collaboration on Cancer Reporting (ICCR). Arch. Pathol. Lab. Med. 2016, 140, 1104–1110. [Google Scholar] [CrossRef] [Green Version]
- Comin, C.E.; Novelli, L.; Cavazza, A.; Rotellini, M.; Cianchi, F.; Messerini, L. Expression of thrombomodulin, calretinin, cytokeratin 5/6, D2-40 and WT-1 in a series of primary carcinomas of the lung: An immunohistochemical study in comparison with epithelioid pleural mesothelioma. Tumori 2014, 100, 559–567. [Google Scholar]
- Kushitani, K.; Amatya, V.J.; Okada, Y.; Katayama, Y.; Mawas, A.S.; Miyata, Y.; Okada, M.; Inai, K.; Kishimoto, T.; Takeshima, Y. Utility and pitfalls of immunohistochemistry in the differential diagnosis between epithelioid mesothelioma and poorly differentiated lung squamous cell carcinoma. Histopathology 2017, 70, 375–384. [Google Scholar] [CrossRef]
- Henderson, D.W.; Reid, G.; Kao, S.C.; van Zandwijk, N.; Klebe, S. Challenges and controversies in the diagnosis of malignant mesothelioma: Part 2. Malignant mesothelioma subtypes, pleural synovial sarcoma, molecular and prognostic aspects of mesothelioma, BAP1, aquaporin-1 and microRNA. J. Clin. Pathol. 2013, 66, 854–861. [Google Scholar] [CrossRef]
- Cigognetti, M.; Lonardi, S.; Fisogni, S.; Balzarini, P.; Pellegrini, V.; Tironi, A.; Bercich, L.; Bugatti, M.; Rossi, G.; Murer, B.; et al. BAP1 (BRCA1-associated protein 1) is a highly specific marker for differentiating mesothelioma from reactive mesothelial proliferations. Mod. Pathol. 2015, 28, 1043–1057. [Google Scholar] [CrossRef] [Green Version]
- Sheffield, B.S.; Hwang, H.C.; Lee, A.F.; Thompson, K.; Rodriguez, S.; Tse, C.H.; Gown, A.M.; Churg, A. BAP1 immunohistochemistry and p16 FISH to separate benign from malignant mesothelial proliferations. Am. J. Surg. Pathol. 2015, 39, 977–982. [Google Scholar] [CrossRef]
- Louw, A.; Lee, Y.C.G.; Acott, N.; Creaney, J.; van Vliet, C.; Chai, S.M. Diagnostic utility of BAP1 for malignant pleural mesothelioma in pleural fluid specimens with atypical morphology. Cytopathology 2022, 33, 84–92. [Google Scholar] [CrossRef]
- Hakim, S.A.; Abou Gabal, H.H. Diagnostic Utility of BAP1, EZH2 and Survivin in Differentiating Pleural Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia: Immunohistochemical Study. Pathol. Oncol. Res. 2021, 27, 600073. [Google Scholar] [CrossRef]
- Pulford, E.; Henderson, D.W.; Klebe, S. Malignant mesothelioma in situ: Diagnostic and clinical considerations. Pathology 2020, 52, 635–642. [Google Scholar] [CrossRef]
- Wang, L.M.; Shi, Z.W.; Wang, J.L.; Ly, Z.; Du, F.B.; Yang, Q.B.; Wang, Y. Diagnostic accuracy of BRCA1-associated protein 1 in malignant mesothelioma: A meta-analysis. Oncotarget 2017, 8, 68863–68872. [Google Scholar] [CrossRef] [Green Version]
- Minami, K.; Jimbo, N.; Tanaka, Y.; Hokka, D.; Miyamoto, Y.; Itoh, T.; Maniwa, Y. Malignant mesothelioma in situ diagnosed by methylthioadenosine phosphorylase loss and homozygous deletion of CDKN2A: A case report. Virchows Arch. 2020, 476, 469–473. [Google Scholar] [CrossRef]
- Henry, M.; Arnold, T.; Harvey, J.; Pleural Diseases Group, Standards of Care Committee, British Thoracic Society. BTS guidelines for the management of spontaneous pneumothorax. Thorax 2003, 58, ii39–ii52. [Google Scholar] [CrossRef] [Green Version]
- Sheard, J.D.; Taylor, W.; Soorae, A.; Pearson, M.G. Pneumothorax and malignant mesothelioma in patients over the age of 40. Thorax 1991, 46, 584–585. [Google Scholar] [CrossRef] [Green Version]
- Bright-Thomas, R.J.; Ahmed, R.Y.; Pearson, S.B.; Muers, M.F.; Luksza, A.R.; Turkington, P.M. Pleural mesothelioma presenting as recurrent pneumothoraces. Br. J. Hosp. Med. 2010, 71, 590–591. [Google Scholar] [CrossRef]
- Kurokawa, T.; Morikawa, T.; Ohtake, S.; Kaji, M.; Sugiura, H.; Okushiba, S.; Kondo, S.; Katoh, H. Spontaneous pneumothorax secondary to radiographically occult lung metastasis from parapharyngeal synovial sarcoma: Report of a case. Surg. Today 2002, 32, 267–269. [Google Scholar] [CrossRef]
- Eisenstadt, H.B. Malignant mesothelioma of the pleura. Dis. Chest 1956, 30, 549–556. [Google Scholar] [CrossRef]
- Alkhuja, S.; Miller, A.; Mastellone, A.J.; Markowitz, S. Malignant pleural mesothelioma presenting as spontaneous pneumothorax: A case series and review. Am. J. Ind. Med. 2000, 38, 219–223. [Google Scholar] [CrossRef]
- Prasad, A.; Olsen, D.; Sriram, P.S. Malignant mesothelioma presenting as a gradually enlarging pneumothorax. Case Rep. Pulmonol. 2013, 2013, 374960. [Google Scholar] [CrossRef]
- Mitsui, A.; Saji, H.; Shimmyo, T.; Mochizuki, A.; Kurimoto, N.; Nakamura, H. Malignant pleural mesothelioma presenting as a spontaneous pneumothorax. Respirol. Case Rep. 2015, 3, 9–12. [Google Scholar] [CrossRef]
- Sattar, N.; Durrance, R.; Khan, A.; Patel, N.; Mora, M.; Shalonov, A. Malignant mesothelioma presenting as recurrent hydro-pneumothorax: An atypical case presentation and literature review. Respir. Med. Case Rep. 2018, 23, 152–155. [Google Scholar] [CrossRef]
- WHO Classification of Tumours Editorial Board. Thoracic Tumours, 5th ed.; International Agency for Research on Cancer: Lyon, France, 2020. [Google Scholar]
- Whitaker, D.; Henderson, D.W.; Shilkin, K.B. The concept of mesothelioma in situ: Implications for diagnosis and histogenesis. Semin. Diagn. Pathol. 1992, 9, 151–161. [Google Scholar]
- Butnor, K.J.; Sporn, T.A.; Hammar, S.P.; Roggli, V. Well-differentiated papillary mesothelioma. Am. J. Surg. Pathol. 2001, 25, 1304–1309. [Google Scholar] [CrossRef]
- Churg, A.; Galateau-Salle, F.; Roden, A.C.; Attanoos, R.; von der Thusen, J.H.; Tsao, M.S.; Chang, N.; De Perrot, M.; Dacic, S. Malignant mesothelioma in situ: Morphologic features and clinical outcome. Mod. Pathol. 2020, 33, 297–302. [Google Scholar] [CrossRef] [PubMed]
- Churg, A.; Dacic, S.; Galateau-Salle, F.; Attanoos, R.; de Perrot, M. Malignant Mesothelioma In Situ: Clinical and Pathologic Implications. J. Thorac. Oncol. 2020, 15, 899–901. [Google Scholar] [CrossRef]
- Popat, S.; Baas, P.; Faivre-Finn, C.; Girard, N.; Nicholson, A.G.; Nowak, A.K.; Opitz, I.; Scherpereel, A.; Reck, M.; ESMO Guidelines Committee. Malignant pleural mesothelioma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann. Oncol. 2021, 26, v31–v39. [Google Scholar] [CrossRef] [PubMed]
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Orlandi, R.; Bono, F.; Cortinovis, D.L.; Cardillo, G.; Cioffi, U.; Guttadauro, A.; Pirondini, E.; Canova, S.; Cassina, E.M.; Raveglia, F. Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold. J. Clin. Med. 2022, 11, 3225. https://doi.org/10.3390/jcm11113225
Orlandi R, Bono F, Cortinovis DL, Cardillo G, Cioffi U, Guttadauro A, Pirondini E, Canova S, Cassina EM, Raveglia F. Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold. Journal of Clinical Medicine. 2022; 11(11):3225. https://doi.org/10.3390/jcm11113225
Chicago/Turabian StyleOrlandi, Riccardo, Francesca Bono, Diego Luigi Cortinovis, Giuseppe Cardillo, Ugo Cioffi, Angelo Guttadauro, Emanuele Pirondini, Stefania Canova, Enrico Mario Cassina, and Federico Raveglia. 2022. "Sneaky Diagnosis of Pleural Malignant Mesothelioma in Thoracic Surgery: All That Glitters Is Not Gold" Journal of Clinical Medicine 11, no. 11: 3225. https://doi.org/10.3390/jcm11113225