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Membranes 2017, 7(1), 6; doi:10.3390/membranes7010006

Recursive Alterations of the Relationship between Simple Membrane Geometry and Insertion of Amphiphilic Motifs

Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, Panum Institute 18.6, University of Copenhagen, Copenhagen N DK-2200, Denmark
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Academic Editor: Shiro Suetsugu
Received: 9 November 2016 / Revised: 23 December 2016 / Accepted: 5 January 2017 / Published: 8 February 2017
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Abstract

The shape and composition of a membrane directly regulate the localization, activity, and signaling properties of membrane associated proteins. Proteins that both sense and generate membrane curvature, e.g., through amphiphilic insertion motifs, potentially engage in recursive binding dynamics, where the recruitment of the protein itself changes the properties of the membrane substrate. Simple geometric models of membrane curvature interactions already provide prediction tools for experimental observations, however these models are treating curvature sensing and generation as separated phenomena. Here, we outline a model that applies both geometric and basic thermodynamic considerations. This model allows us to predict the consequences of recursive properties in such interaction schemes and thereby integrate the membrane as a dynamic substrate. We use this combined model to hypothesize the origin and properties of tubular carrier systems observed in cells. Furthermore, we pinpoint the coupling to a membrane reservoir as a factor that influences the membrane curvature sensing and generation properties of local curvatures in the cell in line with classic determinants such as lipid composition and membrane geometry. View Full-Text
Keywords: amphipathic helix; BAR domain; membrane curvature; curvature sensing; membrane scission; lipid packing defect; surface tension; GUV; liposomes amphipathic helix; BAR domain; membrane curvature; curvature sensing; membrane scission; lipid packing defect; surface tension; GUV; liposomes
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Madsen, K.L.; Herlo, R. Recursive Alterations of the Relationship between Simple Membrane Geometry and Insertion of Amphiphilic Motifs. Membranes 2017, 7, 6.

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