Next Article in Journal / Special Issue
Penetration of HIV-1 Tat47–57 into PC/PE Bilayers Assessed by MD Simulation and X-ray Scattering
Previous Article in Journal
Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6
Previous Article in Special Issue
Multi-Stacked Supported Lipid Bilayer Micropatterning through Polymer Stencil Lift-Off
Article Menu

Export Article

Open AccessReview
Membranes 2015, 5(3), 454-472; doi:10.3390/membranes5030454

Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering

1
Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, 141980 Dubna—Moscow Region, Russia
2
Department of Physical Chemistry of Drugs, Faculty of Pharmacy, Comenius University, 832 32 Bratislava, Slovakia
3
Biology & Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
4
Joint Institute for Neutron Sciences, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6453, USA
5
Department of Physics, University of South Florida, Tampa, FL 33620, USA
6
Department of Physics and Astronomy, University of Tennessee, Knoxville, TN 37996-1200, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Maikel Rheinstadter
Received: 31 July 2015 / Accepted: 15 September 2015 / Published: 21 September 2015
(This article belongs to the Special Issue Membrane Structure and Dynamics)
View Full-Text   |   Download PDF [496 KB, uploaded 21 September 2015]   |  

Abstract

We review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by the sometimes conflicting results found in the literature, even in the case of the most studied lipid bilayers. Increasingly, accurate and detailed structural models require more experimental data, such as those from contrast varied neutron scattering and X-ray scattering experiments that are jointly refined with molecular dynamics simulations. This experimental and computational approach produces robust bilayer structural parameters that enable insights, for example, into the interplay between collective membrane properties and its components (e.g., hydrocarbon chain length and unsaturation, and lipid headgroup composition). From model studies such as these, one is better able to appreciate how a real biological membrane can be tuned by balancing the contributions from the lipid’s different moieties (e.g., acyl chains, headgroups, backbones, etc.). View Full-Text
Keywords: lipidome; bilayer; structure; X-ray scattering; neutron scattering; lipid area lipidome; bilayer; structure; X-ray scattering; neutron scattering; lipid area
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kučerka, N.; Heberle, F.A.; Pan, J.; Katsaras, J. Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering. Membranes 2015, 5, 454-472.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Membranes EISSN 2077-0375 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top