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Membranes 2015, 5(3), 253-287; doi:10.3390/membranes5030253

Endocytosis and Trafficking of Natriuretic Peptide Receptor-A: Potential Role of Short Sequence Motifs

Department of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA
Academic Editor: Morten S. Nielsen
Received: 18 April 2015 / Revised: 25 June 2015 / Accepted: 25 June 2015 / Published: 3 July 2015
(This article belongs to the Special Issue Trafficking of Membrane Receptors 2015)
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Abstract

The targeted endocytosis and redistribution of transmembrane receptors among membrane-bound subcellular organelles are vital for their correct signaling and physiological functions. Membrane receptors committed for internalization and trafficking pathways are sorted into coated vesicles. Cardiac hormones, atrial and brain natriuretic peptides (ANP and BNP) bind to guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA) and elicit the generation of intracellular second messenger cyclic guanosine 3',5'-monophosphate (cGMP), which lowers blood pressure and incidence of heart failure. After ligand binding, the receptor is rapidly internalized, sequestrated, and redistributed into intracellular locations. Thus, NPRA is considered a dynamic cellular macromolecule that traverses different subcellular locations through its lifetime. The utilization of pharmacologic and molecular perturbants has helped in delineating the pathways of endocytosis, trafficking, down-regulation, and degradation of membrane receptors in intact cells. This review describes the investigation of the mechanisms of internalization, trafficking, and redistribution of NPRA compared with other cell surface receptors from the plasma membrane into the cell interior. The roles of different short-signal peptide sequence motifs in the internalization and trafficking of other membrane receptors have been briefly reviewed and their potential significance in the internalization and trafficking of NPRA is discussed. View Full-Text
Keywords: atrial natriuretic peptide; natriuretic peptide receptors; guanylyl cyclase; internalization; receptor trafficking; short sequence motifs atrial natriuretic peptide; natriuretic peptide receptors; guanylyl cyclase; internalization; receptor trafficking; short sequence motifs
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pandey, K.N. Endocytosis and Trafficking of Natriuretic Peptide Receptor-A: Potential Role of Short Sequence Motifs. Membranes 2015, 5, 253-287.

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