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Membranes 2014, 4(3), 333-355; doi:10.3390/membranes4030333

The Endocytic Receptor Megalin and its Associated Proteins in Proximal Tubule Epithelial Cells

1
Division of Clinical Nephrology and Rheumatology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan
2
Department of Applied Molecular Medicine, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan
*
Author to whom correspondence should be addressed.
Received: 31 May 2014 / Revised: 23 June 2014 / Accepted: 1 July 2014 / Published: 11 July 2014
(This article belongs to the Special Issue Trafficking of Membrane Receptors)
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Abstract

Receptor-mediated endocytosis in renal proximal tubule epithelial cells (PTECs) is important for the reabsorption and metabolization of proteins and other substances, including carrier-bound vitamins and trace elements, in glomerular filtrates. Impairment of this endocytic process results in the loss of such substances and development of proteinuria, which is an important clinical indicator of kidney diseases and is also a risk marker for cardiovascular disease. Megalin, a member of the low-density lipoprotein receptor gene family, is a multiligand receptor expressed in the apical membrane of PTECs and plays a central role in the endocytic process. Megalin interacts with various intracellular adaptor proteins for intracellular trafficking and cooperatively functions with other membrane molecules, including the cubilin-amnionless complex. Evidence suggests that megalin and the cubilin-amnionless complex are involved in the uptake of toxic substances into PTECs, which leads to the development of kidney disease. Studies of megalin and its associated molecules will be useful for future development of novel strategies for the diagnosis and treatment of kidney diseases. View Full-Text
Keywords: ARH; clathrin; ClC-5; cubilin; endocytosis; exosome; megalin; NHE3; trafficking ARH; clathrin; ClC-5; cubilin; endocytosis; exosome; megalin; NHE3; trafficking
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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De, S.; Kuwahara, S.; Saito, A. The Endocytic Receptor Megalin and its Associated Proteins in Proximal Tubule Epithelial Cells. Membranes 2014, 4, 333-355.

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