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Membranes 2012, 2(1), 118-133; doi:10.3390/membranes2010118

Mechanisms of Membrane Curvature Generation in Membrane Traffic

1,2,* , 1
Received: 29 January 2012 / Revised: 20 February 2012 / Accepted: 21 February 2012 / Published: 29 February 2012
(This article belongs to the Special Issue Biological Membrane Morphogenesis)
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During the vesicular trafficking process, cellular membranes undergo dynamic morphological changes, in particular at the vesicle generation and fusion steps. Changes in membrane shape are regulated by small GTPases, coat proteins and other accessory proteins, such as BAR domain-containing proteins. In addition, membrane deformation entails changes in the lipid composition as well as asymmetric distribution of lipids over the two leaflets of the membrane bilayer. Given that P4-ATPases, which catalyze unidirectional flipping of lipid molecules from the exoplasmic to the cytoplasmic leaflets of the bilayer, are crucial for the trafficking of proteins in the secretory and endocytic pathways, changes in the lipid composition are involved in the vesicular trafficking process. Membrane remodeling is under complex regulation that involves the composition and distribution of lipids as well as assembly of proteins.
Keywords: membrane trafficking; small GTPase; BAR domain; P4-ATPase; membrane curvature membrane trafficking; small GTPase; BAR domain; P4-ATPase; membrane curvature
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shin, H.-W.; Takatsu, H.; Nakayama, K. Mechanisms of Membrane Curvature Generation in Membrane Traffic. Membranes 2012, 2, 118-133.

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