Next Article in Journal
Reactive Oxygen and Nitrogen Species Regulate Key Metabolic, Anabolic, and Catabolic Pathways in Skeletal Muscle
Previous Article in Journal
Interplay between Oxidative Stress and Platelet Activation in Coronary Thrombus of STEMI Patients
Previous Article in Special Issue
Effects of Reactive Oxygen Species on Tubular Transport along the Nephron
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview
Antioxidants 2018, 7(7), 84; https://doi.org/10.3390/antiox7070084

Transcription Factor ETS-1 and Reactive Oxygen Species: Role in Vascular and Renal Injury

1
Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT 84112, USA
2
Renal Service, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
3
Renal Division, Weill Cornell Medical College, New York, NY 10065, USA
*
Author to whom correspondence should be addressed.
Received: 23 April 2018 / Revised: 15 June 2018 / Accepted: 2 July 2018 / Published: 3 July 2018
(This article belongs to the Special Issue Oxidative Stress and Salt-Sensitive Hypertension)
Full-Text   |   PDF [1547 KB, uploaded 3 July 2018]   |  

Abstract

The E26 avian erythroblastosis virus transcription factor-1 (ETS-1) is a member of the ETS family and regulates the expression of a variety of genes including growth factors, chemokines and adhesion molecules. Although ETS-1 was discovered as an oncogene, several lines of research show that it is up-regulated by angiotensin II (Ang II) both in the vasculature and the glomerulus. While reactive oxygen species (ROS) are required for Ang II-induced ETS-1 expression, ETS-1 also regulates the expression of p47phox, which is one of the subunits of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and a major source of ROS in the kidney and vasculature. Thus, there appears to be a positive feedback between ETS-1 and ROS. ETS-1 is also upregulated in the kidneys of rats with salt-sensitive hypertension and plays a major role in the development of end-organ injury in this animal model. Activation of the renin angiotensin system is required for the increased ETS-1 expression in these rats, and blockade of ETS-1 or haplodeficiency reduces the severity of kidney injury in these rats. In summary, ETS-1 plays a major role in the development of vascular and renal injury and is a potential target for the development of novel therapeutic strategies to ameliorate end-organ injury in hypertension. View Full-Text
Keywords: ETS-1; reactive oxygen species; vascular injury; renal injury ETS-1; reactive oxygen species; vascular injury; renal injury
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Shiu, Y.-T.; Jaimes, E.A. Transcription Factor ETS-1 and Reactive Oxygen Species: Role in Vascular and Renal Injury. Antioxidants 2018, 7, 84.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top