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Antioxidants 2018, 7(7), 83; https://doi.org/10.3390/antiox7070083

Interplay between Oxidative Stress and Platelet Activation in Coronary Thrombus of STEMI Patients

1
Department of Cardiovascular, Respiratory, Nephrology, Anaesthesiology and Geriatric Sciences, Sapienza University of Rome, 00161 Rome, Italy
2
Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, Italy
3
Interventional Cardiology Unit, Santa Maria University Hospital, 05100 Terni, Italy
4
Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica 79, 04100 Latina, Italy
5
Department of AngioCardioNeurology, IRCCS Neuromed, 86077 Pozzilli, Italy
Equally contributors.
*
Author to whom correspondence should be addressed.
Received: 15 May 2018 / Revised: 24 June 2018 / Accepted: 28 June 2018 / Published: 3 July 2018
(This article belongs to the Special Issue Oxidative Stress and Cardiovascular Disease)
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Abstract

Background: Platelet activation and oxidative stress seem to play a key role in coronary thrombus formation and are associated with thrombus burden in ST-elevation myocardial infarction (STEMI). However, the interplay between oxidative stress and platelet activation has not been fully elucidated. Materials and Methods: For 32 patients with STEMI undergoing primary percutaneous coronary intervention (PPCI) and 10 patients with stable angina (SA) and oxidative stress, as assessed by NADPH isoform 2 activity (soluble Nox2-derived peptide, sNox2-dp), levels of oxidized low-density lipoproteins (oxLDLs) and platelet activation markers such as soluble CD40 Ligand (sCD40L) and soluble P-selectin (sP-selectin) were measured in the retrieved material (coronary thrombi plus blood waste) of STEMI patients and in intracoronary blood of SA patients, respectively, and in peripheral blood samples of both groups. Results: In aspirated thrombi and blood waste of STEMI patients we found higher serum levels of sNox2-dp, oxLDLs, sCD40L, and sP-selectin, as compared to the intracoronary blood samples of SA patients. Moreover, in thrombi and blood waste of STEMI patients, a direct correlation between markers of oxidative stress and of platelet activation was found. Also, in STEMI patients a progressive increase of oxidative stress and platelet activation markers was observed according to the thrombus score burden. STEMI patients showed higher peripheral blood Nox2 activity and oxLDL levels as compared to SA patients. Conclusion: This study shows a close relationship between oxidative stress and platelet activation in the intracoronary blood waste and aspirated thrombi of STEMI patients, suggesting a role of oxidative stress in promoting thrombus formation and growth. View Full-Text
Keywords: oxidative stress; STEMI; Thrombolysis in Myocardial Infarction (TIMI) thrombus score; coronary thrombus; platelet activation oxidative stress; STEMI; Thrombolysis in Myocardial Infarction (TIMI) thrombus score; coronary thrombus; platelet activation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Calvieri, C.; Tanzilli, G.; Bartimoccia, S.; Cangemi, R.; Arrivi, A.; Dominici, M.; Cammisotto, V.; Viceconte, N.; Mangieri, E.; Frati, G.; Violi, F. Interplay between Oxidative Stress and Platelet Activation in Coronary Thrombus of STEMI Patients. Antioxidants 2018, 7, 83.

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