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Antioxidants 2018, 7(4), 49; https://doi.org/10.3390/antiox7040049

Sex-Specificity of Oxidative Stress in Newborns Leading to a Personalized Antioxidant Nutritive Strategy

1
Department of Nutrition, Faculty of Medicine, Université de Montréal, Sainte-Justine Hospital, Montréal, QC H3T 1C5, Canada
2
Department Obstetrics & Gynecology, and department of Biochemistry and Molecular Medicine, Faculty of Medicine, University of Montreal, Sainte-Justine Hospital, Montréal, QC H3T 1C5, Canada
*
Author to whom correspondence should be addressed.
Received: 4 March 2018 / Revised: 22 March 2018 / Accepted: 23 March 2018 / Published: 27 March 2018
(This article belongs to the Special Issue Antioxidants: Infant Nutrition)
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Abstract

Oxidative stress is a critical process that triggers several diseases observed in premature infants. Growing recognition of the detriment of oxidative stress in newborns warrants the use of an antioxidant strategy that is likely to be nutritional in order to restore redox homeostasis. It appears essential to have a personalized approach that will take into account the age of gestation at birth and the sex of the infant. However, the link between sex and oxidative stress remains unclear. The aim of this study was to find a common denominator explaining the discrepancy between studies related to sex-specific effects of oxidative stress. Results highlight a specificity of sex in the levels of oxidative stress markers linked to the metabolism of glutathione, as measured in the intracellular compartments. Levels of all sex-dependent oxidative stress markers are greater and markers associated to a better antioxidant defense are lower in boys compared to girls during the neonatal period. This sex-specific discrepancy is likely to be related to estrogen metabolism, which is more active in baby-girls and promotes the activation of glutathione metabolism. Conclusion: our observations suggest that nutritive antioxidant strategies need to target glutathione metabolism and, therefore, should be personalized considering, among others, the sex specificity. View Full-Text
Keywords: sex; gender; oxidative stress marker; newborn; prematurity; glutathione; personalized medicine; antioxidant nutrition sex; gender; oxidative stress marker; newborn; prematurity; glutathione; personalized medicine; antioxidant nutrition
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lavoie, J.-C.; Tremblay, A. Sex-Specificity of Oxidative Stress in Newborns Leading to a Personalized Antioxidant Nutritive Strategy. Antioxidants 2018, 7, 49.

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