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Antioxidants 2018, 7(3), 43; https://doi.org/10.3390/antiox7030043

Microbial Biotransformation of a Polyphenol-Rich Potato Extract Affects Antioxidant Capacity in a Simulated Gastrointestinal Model

1
School of Human Nutrition, McGill University, 21111 Lakeshore, Ste. Anne de Bellevue, QC H9X 3V9, Canada
2
Plant Science Department, McGill University, 21111 Lakeshore, Ste. Anne de Bellevue, QC H9X 3V9, Canada
3
Chemistry Department, University of Quebec at Montreal, 2101 rue Jeanne-Mance, Montreal, QC H2X 2J6, Canada
4
Department of Biomedical Engineering, Duff Medical Building, McGill University, 3775 Rue University, Montreal, QC H3A 2B4, Canada
*
Author to whom correspondence should be addressed.
Received: 26 February 2018 / Revised: 13 March 2018 / Accepted: 15 March 2018 / Published: 20 March 2018
(This article belongs to the Special Issue Dietary Antioxidants and Prevention of Non-Communicable Diseases)
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Abstract

A multistage human gastrointestinal model was used to digest a polyphenol-rich potato extract containing chlorogenic acid, caffeic acid, ferulic acid, and rutin as the primary polyphenols, to assess for their microbial biotransformation and to measure changes in antioxidant capacity in up to 24 h of digestion. The biotransformation of polyphenols was assessed by liquid chromatography–mass spectrometry. Antioxidant capacity was measured by the ferric reducing antioxidant power (FRAP) assay. Among the colonic reactors, parent (poly)phenols were detected in the ascending (AC), but not the transverse (TC) or descending (DC) colons. The most abundant microbial phenolic metabolites in all colonic reactors included derivatives of propionic acid, acetic acid, and benzoic acid. As compared to the baseline, an earlier increase in antioxidant capacity (T = 8 h) was seen in the stomach and small intestine vessels as compared to the AC (T = 16 h) and TC and DC (T = 24 h). The increase in antioxidant capacity observed in the DC and TC can be linked to the accumulation of microbial smaller-molecular-weight phenolic catabolites, as the parent polyphenolics had completely degraded in those vessels. The colonic microbial digestion of potato-based polyphenols could lead to improved colonic health, as this generates phenolic metabolites with significant antioxidant potential. View Full-Text
Keywords: phenolic metabolites; Solanum tuberosum; biotransformation; polyphenols; potato; antioxidant; digestion; gastrointestinal model phenolic metabolites; Solanum tuberosum; biotransformation; polyphenols; potato; antioxidant; digestion; gastrointestinal model
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Khairallah, J.; Sadeghi Ekbatan, S.; Sabally, K.; Iskandar, M.M.; Hussain, R.; Nassar, A.; Sleno, L.; Rodes, L.; Prakash, S.; Donnelly, D.J.; Kubow, S. Microbial Biotransformation of a Polyphenol-Rich Potato Extract Affects Antioxidant Capacity in a Simulated Gastrointestinal Model. Antioxidants 2018, 7, 43.

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