Hormetic Property of Ginseng Steroids on Anti-Oxidant Status against Exercise Challenge in Rat Skeletal Muscle
AbstractBackground: Existing literature on anti-oxidant capacity of ginseng has been inconsistent due to variance in the profile of ginseng steroids (Ginsenosides) that is because of differences in seasons and species. Methods: We used various doses of ginseng steroids to determine its effect on oxidative stress and anti-oxidant capacity of rat skeletal muscle against exercise. Results: Under non-exercise conditions, we found increased thiobarbituric acid reactive substance (TBARS) levels and decreased reduced/oxidized glutathione ratio (GSH/GSSG) in rat skeletal muscle as dose increases (p < 0.05), which indicates the pro-oxidant property of ginseng steroids at baseline. Intriguingly, exhaustive exercise-induced increased TBARS and decreased GSH/GSSG ratio were attenuated with low and medium doses of ginseng steroids (20 and 40 mg per kg), but not with high dose (120 mg per kg). At rest, anti-oxidant enzyme activities, including catalase (CAT), glutathione reductase (GR) and glutathione S-transferase (GST) were increased above vehicle-treated level, but not with the high dose, suggesting a hormetic dose-response of ginseng steroids. Conclusion: The results of this study provide an explanation for the inconsistent findings on anti-oxidative property among previous ginseng studies. For optimizing the anti-oxidant outcome, ginseng supplementation at high dose should be avoided. View Full-Text
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Hsu, M.-F.; Yu, S.-H.; Korivi, M.; Jean, W.-H.; Lee, S.-D.; Huang, C.-Y.; Liao, Y.-H.; Lu, J.; Kuo, C.-H. Hormetic Property of Ginseng Steroids on Anti-Oxidant Status against Exercise Challenge in Rat Skeletal Muscle. Antioxidants 2017, 6, 36.
Hsu M-F, Yu S-H, Korivi M, Jean W-H, Lee S-D, Huang C-Y, Liao Y-H, Lu J, Kuo C-H. Hormetic Property of Ginseng Steroids on Anti-Oxidant Status against Exercise Challenge in Rat Skeletal Muscle. Antioxidants. 2017; 6(2):36.Chicago/Turabian Style
Hsu, Ming-Fen; Yu, Szu-Hsien; Korivi, Mallikarjuna; Jean, Wei-Horng; Lee, Shin-Da; Huang, Chih-Yang; Liao, Yi-Hung; Lu, Jessica; Kuo, Chia-Hua. 2017. "Hormetic Property of Ginseng Steroids on Anti-Oxidant Status against Exercise Challenge in Rat Skeletal Muscle." Antioxidants 6, no. 2: 36.