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Antioxidants 2017, 6(2), 29; doi:10.3390/antiox6020029

HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation

Department of Experimental Medicine, University of Genoa, Via L. B. Alberti 2, Genoa 16132, Italy
Bambino Gesù Children’s Hospital, IRCCS, Piazza S. Onofrio 4, Rome 00165, Italy
Giannina Gaslini Institute, IRCCS, Via Gerolamo Gaslini 5, Genoa 16147, Italy
Author to whom correspondence should be addressed.
Academic Editor: Debasis Mondal
Received: 31 March 2017 / Revised: 26 April 2017 / Accepted: 29 April 2017 / Published: 5 May 2017
(This article belongs to the Special Issue Oxidative Stress and Cancer: The Nrf2 Enigma)
View Full-Text   |   Download PDF [853 KB, uploaded 5 May 2017]   |  


The upregulation of heme oxygenase-1 (HO-1) is one of the most important mechanisms of cell adaptation to stress. Indeed, the redox sensitive transcription factor Nrf2 is the pivotal regulator of HO-1 induction. Through the antioxidant, antiapoptotic, and antinflammatory properties of its metabolic products, HO-1 plays a key role in healthy cells in maintaining redox homeostasis and in preventing carcinogenesis. Nevertheless, several lines of evidence have highlighted the role of HO-1 in cancer progression and its expression correlates with tumor growth, aggressiveness, metastatic and angiogenetic potential, resistance to therapy, tumor escape, and poor prognosis, even though a tumor- and tissue-specific activity has been observed. In this review, we summarize the current literature regarding the pro-tumorigenic role of HO-1 dependent tumor progression as a promising target in anticancer strategy. View Full-Text
Keywords: HO-1; Nrf2; cancer progression; tumor microenvironment; immune-escape; oxidative stress; NK; melanoma; NSCLC; prostate cancer HO-1; Nrf2; cancer progression; tumor microenvironment; immune-escape; oxidative stress; NK; melanoma; NSCLC; prostate cancer

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Nitti, M.; Piras, S.; Marinari, U.M.; Moretta, L.; Pronzato, M.A.; Furfaro, A.L. HO-1 Induction in Cancer Progression: A Matter of Cell Adaptation. Antioxidants 2017, 6, 29.

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