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Antioxidants 2017, 6(1), 18; doi:10.3390/antiox6010018

Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress

1
Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA
2
Department of Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25701, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Dewan S. A. Majid
Received: 23 January 2017 / Revised: 10 February 2017 / Accepted: 22 February 2017 / Published: 2 March 2017
(This article belongs to the Special Issue Oxidative Stress and Salt-Sensitive Hypertension)
View Full-Text   |   Download PDF [437 KB, uploaded 2 March 2017]   |  

Abstract

Other than genetic regulation of salt sensitivity of blood pressure, many factors have been shown to regulate renal sodium handling which contributes to long-term blood pressure regulation and have been extensively reviewed. Here we present our progress on the Na/K-ATPase signaling mediated sodium reabsorption in renal proximal tubules, from cardiotonic steroids-mediated to reactive oxygen species (ROS)-mediated Na/K-ATPase signaling that contributes to experimental salt sensitivity. View Full-Text
Keywords: Na/K-ATPase; signaling; cardiotonic steroids; ROS; renal sodium handling; salt sensitivity Na/K-ATPase; signaling; cardiotonic steroids; ROS; renal sodium handling; salt sensitivity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Liu, J.; Yan, Y.; Nie, Y.; Shapiro, J.I. Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress. Antioxidants 2017, 6, 18.

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