Next Article in Journal
Na/K-ATPase Signaling and Salt Sensitivity: The Role of Oxidative Stress
Previous Article in Journal
The Effect of Gender and Menstrual Phase on Serum Creatine Kinase Activity and Muscle Soreness Following Downhill Running
Previous Article in Special Issue
Treating Cancer by Targeting Telomeres and Telomerase
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessReview
Antioxidants 2017, 6(1), 17; doi:10.3390/antiox6010017

Current Insights to Regulation and Role of Telomerase in Human Diseases

1
Division of Cancer Genetics and Therapeutics, Laboratory of NFκB Signaling, Institute of Molecular and Cell Biology (IMCB), A*STAR (Agency for Science, Technology and Research), Singapore 138673, Singapore
2
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore (NUS), Singapore 117597, Singapore
3
Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide SA 5000, Australia
*
Author to whom correspondence should be addressed.
Academic Editor: Gabriele Saretzki
Received: 24 January 2017 / Revised: 16 February 2017 / Accepted: 21 February 2017 / Published: 28 February 2017
(This article belongs to the Special Issue Role of Telomerase in Aging and Cancer)
View Full-Text   |   Download PDF [439 KB, uploaded 28 February 2017]   |  

Abstract

The telomerase ribonucleoprotein complex has a pivotal role in regulating the proliferation and senescence of normal somatic cells as well as cancer cells. This complex is comprised mainly of telomerase reverse transcriptase (TERT), telomerase RNA component (TERC) and other associated proteins that function to elongate telomeres localized at the end of the chromosomes. While reactivation of telomerase is a major hallmark of most cancers, together with the synergistic activation of other oncogenic signals, deficiency in telomerase and telomeric proteins might lead to aging and senescence-associated disorders. Therefore, it is critically important to understand the canonical as well as non-canonical functions of telomerase through TERT to develop a therapeutic strategy against telomerase-related diseases. In this review, we shed light on the regulation and function of telomerase, and current therapeutic strategies against telomerase in cancer and age-related diseases. View Full-Text
Keywords: telomerase; telomerase reverse transcriptase (TERT); hTERT promoter mutations; telomerase RNA component (TERC); telomere; cancer; age-related diseases telomerase; telomerase reverse transcriptase (TERT); hTERT promoter mutations; telomerase RNA component (TERC); telomere; cancer; age-related diseases
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Ozturk, M.B.; Li, Y.; Tergaonkar, V. Current Insights to Regulation and Role of Telomerase in Human Diseases. Antioxidants 2017, 6, 17.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top