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Antioxidants 2016, 5(4), 46; doi:10.3390/antiox5040046

The Effects of Different Garlic-Derived Allyl Sulfides on Anaerobic Sulfur Metabolism in the Mouse Kidney

Chair of Medical Biochemistry, Medical College, Jagiellonian University, Kopernika 7, Kraków 31-034, Poland
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Academic Editors: Claus Jacob and Gregory Ian Giles
Received: 5 September 2016 / Revised: 3 November 2016 / Accepted: 22 November 2016 / Published: 5 December 2016
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Abstract

Diallyl sulfide (DAS), diallyl disulfide (DADS) and diallyl trisulfide (DATS) are major oil-soluble organosulfur compounds of garlic responsible for most of its pharmacological effects. The present study investigated the influence of repeated intraperitoneally (ip) administration of DAS, DADS and DATS on the total level of sulfane sulfur, bound sulfur (S-sulfhydration) and hydrogen sulfide (H2S) and on the activity of enzymes, which catalyze sulfane sulfur formation and transfer from a donor to an acceptor in the normal mouse kidney, i.e., γ-cystathionase (CSE) and rhodanese (TST). The activity of aldehyde dehydrogenase (ALDH), which is a redox-sensitive protein, containing an –SH group in its catalytic center, was also determined. The obtained results indicated that all tested compounds significantly increased the activity of TST. Moreover, DADS and DATS increased the total sulfane sulfur level and CSE activity in the normal mouse kidney. ALDH activity was inhibited in the kidney after DATS administration. The results indicated also that none of the studied allyl sulfides affected the level of bound sulfur or H2S. Thus, it can be concluded that garlic-derived DADS and DATS can be a source of sulfane sulfur for renal cells but they are not connected with persulfide formation. View Full-Text
Keywords: sulfane sulfur; hydrogen sulfide; bound sulfur; allyl sulfides; aldehyde dehydrogenase; kidney sulfane sulfur; hydrogen sulfide; bound sulfur; allyl sulfides; aldehyde dehydrogenase; kidney
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Iciek, M.; Bilska-Wilkosz, A.; Górny, M.; Sokołowska-Jeżewicz, M.; Kowalczyk-Pachel, D. The Effects of Different Garlic-Derived Allyl Sulfides on Anaerobic Sulfur Metabolism in the Mouse Kidney. Antioxidants 2016, 5, 46.

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