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Antioxidants 2016, 5(1), 4; doi:10.3390/antiox5010004

Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung

1
Health Research Institute (HRI), National Institute of Advanced Industrial Science and Technology (AIST), 2217-14 Hayashi-cho, Takamatsu 761-0301, Kagawa, Japan
2
Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahata-nishi-ku, Kitakyushu, Fukuoka 807-8555, Japan
3
Department of Chemical Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8527, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Vytas Reipa
Received: 17 November 2015 / Revised: 29 December 2015 / Accepted: 5 January 2016 / Published: 18 January 2016
(This article belongs to the Special Issue Nanomaterial Oxidative Stress)
View Full-Text   |   Download PDF [1679 KB, uploaded 18 January 2016]   |  

Abstract

NiO nanoparticles were administered to rat lungs via intratracheal instillation or inhalation. During pulmonary toxicity caused by NiO nanoparticles, the induction of oxidative stress is a major factor. Both intratracheal instillation and inhalation of NiO nanoparticles induced pulmonary oxidative stress. The oxidative stress response protein, heme oxygenase-1 (HO-1), was induced by the administration of NiO nanoparticles at both the protein and gene expression level. Additionally, certain oxidative-stress markers in the lung, such as 8-iso-prostaglandin F2α, thioredoxin, and inducible nitric oxide synthase were increased. Furthermore, the concentration of myeloperoxidase (MPO) in the lung was also increased by the administration of NiO nanoparticles. When the amount of NiO in the lung is similar, the responses against pulmonary oxidative stress of intratracheal instillation and inhalation are also similar. However, the state of pulmonary oxidative stress in the early phase was different between intratracheal instillation and inhalation, even if the amount of NiO in the lung was similar. Inhalation causes milder oxidative stress than that caused by intratracheal instillation. On evaluation of the nanoparticle-induced pulmonary oxidative stress in the early phase, we should understand the different states of oxidative stress induced by intratracheal instillation and inhalation. View Full-Text
Keywords: oxidative stress; nanoparticle; nickel oxide; inhalation; intratracheal instillation oxidative stress; nanoparticle; nickel oxide; inhalation; intratracheal instillation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Horie, M.; Yoshiura, Y.; Izumi, H.; Oyabu, T.; Tomonaga, T.; Okada, T.; Lee, B.-W.; Myojo, T.; Kubo, M.; Shimada, M.; Morimoto, Y. Comparison of the Pulmonary Oxidative Stress Caused by Intratracheal Instillation and Inhalation of NiO Nanoparticles when Equivalent Amounts of NiO Are Retained in the Lung. Antioxidants 2016, 5, 4.

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