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Antioxidants 2015, 4(4), 750-767; doi:10.3390/antiox4040750

Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites

1
Sami Labs Limited, Bangalore 560058, India
2
Sabinsa Corporation-East Windsor, NJ 08520, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Michael Breitenbach
Received: 24 September 2015 / Revised: 29 October 2015 / Accepted: 2 November 2015 / Published: 2 December 2015
View Full-Text   |   Download PDF [232 KB, uploaded 2 December 2015]   |  

Abstract

Curcumin metabolites namely curcumin monoglucuronide and curcumin diglucuronide were synthesized using an alternative synthetic approach. The anti-oxidant potential of these curcumin glucuronides was compared with that of curcumin using DPPH scavenging method and Oxygen Radical Absorbance Capacity (ORAC) assay. The results show that curcumin monoglucuronide exhibits 10 fold less anti-oxidant activity (DPPH method) and the anti-oxidant capacity of curcumin diglucuronide is highly attenuated compared to the anti-oxidant activity of curcumin. View Full-Text
Keywords: curcumin monoglucuronide; curcumin diglucuronide; Synthesis; Anti-oxidant; DPPH; ORAC curcumin monoglucuronide; curcumin diglucuronide; Synthesis; Anti-oxidant; DPPH; ORAC
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Choudhury, A.K.; Raja, S.; Mahapatra, S.; Nagabhushanam, K.; Majeed, M. Synthesis and Evaluation of the Anti-Oxidant Capacity of Curcumin Glucuronides, the Major Curcumin Metabolites. Antioxidants 2015, 4, 750-767.

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