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Antioxidants 2014, 3(1), 144-158; doi:10.3390/antiox3010144

Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies

1
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269-4017, USA
2
Center on Aging, University of Connecticut Health Center, Farmington, CT 06030-5215, USA
*
Author to whom correspondence should be addressed.
Received: 31 December 2013 / Revised: 23 February 2014 / Accepted: 24 February 2014 / Published: 11 March 2014
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Abstract

Bone loss during aging has become an increasing public health concern as average life expectancy has increased. One of the most prevalent forms of age-related bone disease today is osteoporosis in which the body slows down bone formation and existing bone is increasingly being resorbed by the body to maintain the calcium balance. Some causes of this bone loss can be attributed to dysregulation of osteoblast and osteoclast activity mediated by increased oxidative stress through the aging process. Due to certain serious adverse effects of the currently available therapeutic agents that limit their efficacy, complementary and alternative medicine (CAM) has garnered interest as a natural means for the prevention of this debilitating disease. Natural antioxidant supplementation, a type of CAM, has been researched to aid in reducing bone loss caused by oxidative stress. Naturally occurring polyphenols, such as anthocyanins rich in berries, are known to have anti-oxidative properties. Several studies have been reviewed to determine the impact polyphenol intake—particularly that of berries—has on bone health. Studies reveal a positive association of high berry intake and higher bone mass, implicating berries as possible inexpensive alternatives in reducing the risk of age related bone loss. View Full-Text
Keywords: aging; bone loss; osteoporosis; oxidative stress; berries; polyphenols; anthocyanins aging; bone loss; osteoporosis; oxidative stress; berries; polyphenols; anthocyanins
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hubert, P.A.; Lee, S.G.; Lee, S.-K.; Chun, O.K. Dietary Polyphenols, Berries, and Age-Related Bone Loss: A Review Based on Human, Animal, and Cell Studies. Antioxidants 2014, 3, 144-158.

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