Antioxidants 2013, 2(3), 100-109; doi:10.3390/antiox2030100
Article

Organic and Conventional Yerba Mate (Ilex paraguariensis A. St. Hil) Improves Metabolic Redox Status of Liver and Serum in Wistar Rats

Received: 20 May 2013; in revised form: 20 June 2013 / Accepted: 12 July 2013 / Published: 24 July 2013
(This article belongs to the Special Issue Dietary Antioxidants)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Organic and conventional yerba mate (Ilex paraguariensis) is widely used in South America to prepare nonalcoholic drinks rich in polyphenols. These compounds are able to prevent the generation of reactive species, thus minimizing the incidence of several diseases. In this perspective, we hypothesized that yerba mate may have protective effects against pentylenetetrazol (PTZ)-induced oxidative damage in liver and serum of rats. Animals (n = 42) received distilled water (control) or yerba mate (organic or conventional) for fifteen days. Then, half of the rats of each group received 60 mg/kg PTZ intraperitoneally or saline solution. After 30 min the animals were euthanized and the liver and blood were collected. The results showed that organic and conventional yerba mate avoided PTZ-induced oxidative damage and nitric oxide production in the liver and serum of the rats. Moreover, both kinds of yerba mate prevented the decrease in enzymatic (superoxide dismutase and catalase) and non-enzymatic (sulfhydryl protein content) defenses in the liver and serum. In addition, histopathologic analysis of the liver showed that yerba mate reduced PTZ-induced cell damage. These findings indicate that yerba mate provides hepatoprotection and improves antioxidant status in the serum, which may contribute to the development of new therapeutic strategies using nutraceuticals drinks.
Keywords: yerba mate; polyphenols; antioxidant; nutraceutical
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MDPI and ACS Style

Branco, C.S.; Scola, G.; Rodrigues, A.D.; Cesio, V.; Heinzen, H.; Godoy, A.; Funchal, C.; Coitinho, A.S.; Salvador, M. Organic and Conventional Yerba Mate (Ilex paraguariensis A. St. Hil) Improves Metabolic Redox Status of Liver and Serum in Wistar Rats. Antioxidants 2013, 2, 100-109.

AMA Style

Branco CS, Scola G, Rodrigues AD, Cesio V, Heinzen H, Godoy A, Funchal C, Coitinho AS, Salvador M. Organic and Conventional Yerba Mate (Ilex paraguariensis A. St. Hil) Improves Metabolic Redox Status of Liver and Serum in Wistar Rats. Antioxidants. 2013; 2(3):100-109.

Chicago/Turabian Style

Branco, Cátia S.; Scola, Gustavo; Rodrigues, Adriana D.; Cesio, Verónica; Heinzen, Horacio; Godoy, Alessandra; Funchal, Cláudia; Coitinho, Adriana S.; Salvador, Mirian. 2013. "Organic and Conventional Yerba Mate (Ilex paraguariensis A. St. Hil) Improves Metabolic Redox Status of Liver and Serum in Wistar Rats." Antioxidants 2, no. 3: 100-109.

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