Next Article in Journal
Comparative Study of Antioxidant Power, Polyphenols, Flavonoids and Betacyanins of the Peel and Pulp of Three Tunisian Opuntia Forms
Previous Article in Journal
Antioxidant Capacity of Selected Plant Extracts and Their Essential Oils
Antioxidants 2013, 2(1), 23-36; doi:10.3390/antiox2010023
Article

Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements

1
, 2,†
, 2,†
, 3
 and 1,*
Received: 6 November 2012; in revised form: 27 December 2012 / Accepted: 25 January 2013 / Published: 6 February 2013
View Full-Text   |   Download PDF [898 KB, updated 18 February 2013; original version uploaded 6 February 2013]   |   Browse Figures
Abstract: Milk thistle dietary supplements that contain silymarin are widely marketed and used in the USA and other countries for liver enhancement and recovery. More recently, silymarin has also been identified as a possible antiviral for the treatment of hepatitis C virus (HCV) infection. To assess different brands of commercially sold silymarin, 45 products were collected from local stores and analyzed for their silymarin content, antioxidant activities, and antiviral activity against HCV. Antioxidant activity was measured as radical scavenging activity using DPPH and by estimating their antioxidant capacity as trolox equivalent. Anti-HCV activity was measured in an HCV genotype 1b replication inhibition assay. Samples were found to vary widely in their silymarin content, with some samples having none or very low concentrations while silymarin represented higher than 80% of other samples. Both antioxidant and anti-HCV activity correlated with the overall level of silymarin.
Keywords: Silybum marianum; radical scavenger; food supplement; over the counter drugs; hepatitis C virus Silybum marianum; radical scavenger; food supplement; over the counter drugs; hepatitis C virus
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Anthony, K.; Subramanya, G.; Uprichard, S.; Hammouda, F.; Saleh, M. Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements. Antioxidants 2013, 2, 23-36.

AMA Style

Anthony K, Subramanya G, Uprichard S, Hammouda F, Saleh M. Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements. Antioxidants. 2013; 2(1):23-36.

Chicago/Turabian Style

Anthony, Kevin; Subramanya, Gitanjali; Uprichard, Susan; Hammouda, Faiza; Saleh, Mahmoud. 2013. "Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements." Antioxidants 2, no. 1: 23-36.


Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert