Next Article in Journal
Comparative Study of Antioxidant Power, Polyphenols, Flavonoids and Betacyanins of the Peel and Pulp of Three Tunisian Opuntia Forms
Previous Article in Journal
Antioxidant Capacity of Selected Plant Extracts and Their Essential Oils
Article Menu

Export Article

Open AccessArticle
Antioxidants 2013, 2(1), 23-36; doi:10.3390/antiox2010023

Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements

1
Department of Chemistry, Texas Southern University, Houston, TX 77004, USA
2
Department of Medicine, University of Illinois Chicago, Chicago, IL 60612, USA
3
Department of Phytochemistry, National Research Center, Dokki 12311, Cairo, Egypt
Current Address: Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA.
*
Author to whom correspondence should be addressed.
Received: 6 November 2012 / Revised: 27 December 2012 / Accepted: 25 January 2013 / Published: 6 February 2013
View Full-Text   |   Download PDF [898 KB, 18 February 2013; original version 6 February 2013]   |  

Abstract

Milk thistle dietary supplements that contain silymarin are widely marketed and used in the USA and other countries for liver enhancement and recovery. More recently, silymarin has also been identified as a possible antiviral for the treatment of hepatitis C virus (HCV) infection. To assess different brands of commercially sold silymarin, 45 products were collected from local stores and analyzed for their silymarin content, antioxidant activities, and antiviral activity against HCV. Antioxidant activity was measured as radical scavenging activity using DPPH and by estimating their antioxidant capacity as trolox equivalent. Anti-HCV activity was measured in an HCV genotype 1b replication inhibition assay. Samples were found to vary widely in their silymarin content, with some samples having none or very low concentrations while silymarin represented higher than 80% of other samples. Both antioxidant and anti-HCV activity correlated with the overall level of silymarin.
Keywords: Silybum marianum; radical scavenger; food supplement; over the counter drugs; hepatitis C virus Silybum marianum; radical scavenger; food supplement; over the counter drugs; hepatitis C virus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Anthony, K.; Subramanya, G.; Uprichard, S.; Hammouda, F.; Saleh, M. Antioxidant and Anti-Hepatitis C Viral Activities of Commercial Milk Thistle Food Supplements. Antioxidants 2013, 2, 23-36.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Antioxidants EISSN 2076-3921 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top