Peroxiredoxins as Potential Targets for Cardiovascular Disease
Round 1
Reviewer 1 Report
The description of the Prxs is suitable for a review such as this. The role of Prx in cellular physiology is a little outside my area of expertise but the review is an extensive survey of the current findings.
Reviewer 2 Report
The manuscript is very well-written and succinct in style. The work of others seems to be referenced comprehensively and the standard of presentation is very high. I am not a specialist in this field but to a generally interested reader in the structural biology field, it comes across as an informative review article. As an entirely optional suggestion, perhaps the information on structural data could be expanded somewhat and maybe include a figure of a representative enzyme and its active site?
Reviewer 3 Report
The present submitted review deals with the role of antioxidant enzymes Prdxs in the regulation of reactive oxygen species-induced pathological changes in the development of cardiovascular disease.
I find that the scientific problem discussed in this Review is original and of scientific interest and the reported literature references and discussion are updated, huge and complete.
