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Microarrays 2015, 4(2), 115-132; doi:10.3390/microarrays4020115

Aptamer Microarrays—Current Status and Future Prospects

Institut für Technische Chemie, Leibniz Universität Hannover, Callinstrasse 3, 30167 Hannover, Germany
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Academic Editor: Günter Roth
Received: 30 January 2015 / Revised: 9 March 2015 / Accepted: 18 March 2015 / Published: 24 March 2015
(This article belongs to the Special Issue New and Old Technologies for Generation of Microarrays)
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Abstract

Microarray technologies are state of the art in biological research, which requires fast genome, proteome and transcriptome analysis technologies. Often antibodies are applied in protein microarrays as proteomic tools. Since the generation of antibodies against toxic targets or small molecules including organic compounds remains challenging the use of antibodies may be limited in this context. In contrast to this, aptamer microarrays provide alternative techniques to circumvent these limitations. In this article we review the latest developments in aptamer microarray technology. We discuss similarities and differences between DNA and aptamer microarrays and shed light on the post synthesis immobilization of aptamers including corresponding effects on the microarray performance. Finally, we highlight current limitations and future prospects of aptamer microarray technology. View Full-Text
Keywords: aptamer; microarray; multiplex; protein detection; small molecules aptamer; microarray; multiplex; protein detection; small molecules
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Witt, M.; Walter, J.-G.; Stahl, F. Aptamer Microarrays—Current Status and Future Prospects. Microarrays 2015, 4, 115-132.

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