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Microarrays 2013, 2(2), 115-130; doi:10.3390/microarrays2020115
Article

A Flexible Microarray Data Simulation Model

Received: 1 March 2013 / Revised: 7 April 2013 / Accepted: 15 April 2013 / Published: 17 April 2013
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Abstract

Microarray technology allows monitoring of gene expression profiling at the genome level. This is useful in order to search for genes involved in a disease. The performances of the methods used to select interesting genes are most often judged after other analyzes (qPCR validation, search in databases...), which are also subject to error. A good evaluation of gene selection methods is possible with data whose characteristics are known, that is to say, synthetic data. We propose a model to simulate microarray data with similar characteristics to the data commonly produced by current platforms. The parameters used in this model are described to allow the user to generate data with varying characteristics. In order to show the flexibility of the proposed model, a commented example is given and illustrated. An R package is available for immediate use.
Keywords: microarray data; simulation model; R code microarray data; simulation model; R code
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dembélé, D. A Flexible Microarray Data Simulation Model. Microarrays 2013, 2, 115-130.

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