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Brain Sci. 2018, 8(1), 5; https://doi.org/10.3390/brainsci8010005

Extent of Resection in Newly Diagnosed Glioblastoma: Impact of a Specialized Neuro-Oncology Care Center

1
Wilhelm Sander Neuro-Oncology Unit, University Medical Center Regensburg, 93053 Regensburg, Germany
2
Department of Neurosurgery, University Medical Center Regensburg, 93053 Regensburg, Germany
3
Department of Neurology, University Medical Center Regensburg, 93053 Regensburg, Germany
4
Department of Radiation Oncology, University Medical Center Regensburg, 93053 Regensburg, Germany
5
Department of Neuropathology, University Medical Center Regensburg, 93053 Regensburg, Germany
6
Department of Neuroradiology, University Medical Center Regensburg, 93053 Regensburg, Germany
7
Tumor Center Regensburg, Institute of Quality Assurance and Health Services Research, University of Regensburg, 93053 Regensburg, Germany
8
Department of Hematology and Oncology, University Medical Center Regensburg, 93053 Regensburg, Germany
*
Author to whom correspondence should be addressed.
Received: 2 October 2017 / Revised: 7 December 2017 / Accepted: 19 December 2017 / Published: 25 December 2017
(This article belongs to the Special Issue Advances in Adult and Pediatric Brain Tumor Management)
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Abstract

Treatment of glioblastoma (GBM) consists of microsurgical resection followed by concomitant radiochemotherapy and adjuvant chemotherapy. The best outcome regarding progression free (PFS) and overall survival (OS) is achieved by maximal resection. The foundation of a specialized neuro-oncology care center (NOC) has enabled the implementation of a large technical portfolio including functional imaging, awake craniotomy, PET scanning, fluorescence-guided resection, and integrated postsurgical therapy. This study analyzed whether the technically improved neurosurgical treatment structure yields a higher rate of complete resection, thus ultimately improving patient outcome. Patients and methods: The study included 149 patients treated surgically for newly diagnosed GBM. The neurological performance score (NPS) and the Karnofsky performance score (KPS) were measured before and after resection. The extent of resection (EOR) was volumetrically quantified. Patients were stratified into two subcohorts: treated before (A) and after (B) the foundation of the Regensburg NOC. The EOR and the PFS and OS were evaluated. Results: Prognostic factors for PFS and OS were age, preoperative KPS, O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status, isocitrate dehydrogenase 1 (IDH1) mutation status and EOR. Patients with volumetrically defined complete resection had significantly better PFS (9.4 vs. 7.8 months; p = 0.042) and OS (18.4 vs. 14.5 months; p = 0.005) than patients with incomplete resection. The frequency of transient or permanent postoperative neurological deficits was not higher after complete resection in both subcohorts. The frequency of complete resection was significantly higher in subcohort B than in subcohort A (68.2% vs. 34.8%; p = 0.007). Accordingly, subcohort B showed significantly longer PFS (8.6 vs. 7.5 months; p = 0.010) and OS (18.7 vs. 12.4 months; p = 0.001). Multivariate Cox regression analysis showed complete resection, age, preoperative KPS, and MGMT promoter status as independent prognostic factors for PFS and OS. Our data show a higher frequency of complete resection in patients with GBM after the establishment of a series of technical developments that resulted in significantly better PFS and OS without increasing surgery-related morbidity. View Full-Text
Keywords: resection; glioblastoma; fluorescence guidance; functional imaging; outcome resection; glioblastoma; fluorescence guidance; functional imaging; outcome
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Haj, A.; Doenitz, C.; Schebesch, K.-M.; Ehrensberger, D.; Hau, P.; Putnik, K.; Riemenschneider, M.J.; Wendl, C.; Gerken, M.; Pukrop, T.; Brawanski, A.; Proescholdt, M.A. Extent of Resection in Newly Diagnosed Glioblastoma: Impact of a Specialized Neuro-Oncology Care Center. Brain Sci. 2018, 8, 5.

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