Next Article in Journal
Localization of Fibrinogen in the Vasculo-Astrocyte Interface after Cortical Contusion Injury in Mice
Next Article in Special Issue
Creativity Assessment in Subjects with Tourette Syndrome vs. Patients with Parkinson’s Disease: A Preliminary Study
Previous Article in Journal
Subtitling for d/Deaf and Hard-of-Hearing Children: Current Practices and New Possibilities to Enhance Language Development
Previous Article in Special Issue
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder
Article Menu

Export Article

Open AccessArticle
Brain Sci. 2017, 7(7), 76; doi:10.3390/brainsci7070076

P300 Source Localization Contrasts in Body-Focused Repetitive Behaviors and Tic Disorders

1
Department of Psychiatry, McGill University, Montréal, QC H3A 1A1, Canada
2
Cognitive and Social Psychophysiology Lab, Centre de Recherche de L’Institut Universitaire en Santé Mentale de Montréal, 7331 Hochelaga Street, Montréal, QC H1N 3V2, Canada
3
Department of Neurosciences, Université de Montréal, Montréal, QC H3T 1J4, Canada
4
Department of Psychiatry, Université de Montréal, Montréal, QC H3T 1J4, Canada
5
Centre D’études sur les Troubles Obsessionnels-Compulsifs et les Tics, Centre de Recherche de L’Institut Universitaire en Santé Mentale de Montréal, 7331 Hochelaga Street, Montréal, QC H1N 3V2, Canada
6
Department of Stomatology, Faculty of Dental Medicine, Université de Montréal, Montréal, QC H3T 1J4, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Wai Kwong Tang
Received: 6 May 2017 / Revised: 25 June 2017 / Accepted: 27 June 2017 / Published: 1 July 2017
(This article belongs to the Special Issue Cerebral Etiology and Treatment of the Gilles de la Tourette Syndrome)
View Full-Text   |   Download PDF [5869 KB, uploaded 1 July 2017]   |  

Abstract

Tic disorders (TD) and body-focused repetitive behaviors (BFRB) have similar phenotypes that can be challenging to distinguish in clinical settings. Both disorders show high rates of comorbid psychiatric conditions, dysfunctional basal ganglia activity, atypical cortical functioning in the prefrontal and motor cortical regions, and cognitive deficits. Clinicians frequently confound the two disorders and it is important to find reliable objective methods to discriminate TD and BFRB. Neuropsychological tests and event-related potential (ERP) studies have yielded inconsistent results regarding a possible context updating deficit in TD and BFRB patients. However, most previous studies did not control for the presence of comorbid psychiatric condition and medication status, which might have confounded the findings reported to date. Hence, we aimed to investigate the psychophysiology of working memory using ERP in carefully screened TD and BFRB patients excluding those with psychiatric comorbidity and those taking psychoactive medication. The current study compared 12 TD patients, 12 BRFB patients, and 15 healthy control participants using a motor oddball task (button press). The P300 component was analyzed as an index of working memory functioning. Results showed that BFRB patients had decreased P300 oddball effect amplitudes over the right hemisphere compared to the TD and control groups. Clinical groups presented different scalp distributions compared to controls, which could represent a potential endophenotype candidate of BFRB and TD. View Full-Text
Keywords: body-focused repetitive behaviors; Tourette syndrome; tics; event-related potentials; electrophysiology; P300; context updating body-focused repetitive behaviors; Tourette syndrome; tics; event-related potentials; electrophysiology; P300; context updating
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Sauvé, G.; Morand-Beaulieu, S.; O’Connor, K.P.; Blanchet, P.J.; Lavoie, M.E. P300 Source Localization Contrasts in Body-Focused Repetitive Behaviors and Tic Disorders. Brain Sci. 2017, 7, 76.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top