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Brain Sci. 2017, 7(1), 8; doi:10.3390/brainsci7010008

Sex Differences in Neuromuscular Fatigability of the Knee Extensors Post-Stroke

1
Department of Physical Therapy, Marquette University, Milwaukee, WI 53201, USA
2
Department of Occupational Therapy, Concordia University, Mequon, WI 53097, USA
3
Department of Physical Medicine and Rehabilitation, Medical College of Wisconsin, Milwaukee, WI 53201, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Sheila Schindler-Ivens
Received: 3 November 2016 / Revised: 19 December 2016 / Accepted: 6 January 2017 / Published: 12 January 2017
(This article belongs to the Special Issue Functional Recovery after Stroke)
View Full-Text   |   Download PDF [651 KB, uploaded 12 January 2017]   |  

Abstract

Background and Purpose: Despite the implications of optimizing strength training post-stroke, little is known about the differences in fatigability between men and women with chronic stroke. The purpose of this study was to determine the sex differences in knee extensor muscle fatigability and potential mechanisms in individuals with stroke. Methods: Eighteen participants (10 men, eight women) with chronic stroke (≥6 months) and 23 (12 men, 11 women) nonstroke controls participated in the study. Participants performed an intermittent isometric contraction task (6 s contraction, 3 s rest) at 30% of maximal voluntary contraction (MVC) torque until failure to maintain the target torque. Electromyography was used to determine muscle activation and contractile properties were assessed with electrical stimulation of the quadriceps muscles. Results: Individuals with stroke had a briefer task duration (greater fatigability) than nonstroke individuals (24.1 ± 17 min vs. 34.9 ± 16 min). Men were more fatigable than women for both nonstroke controls and individuals with stroke (17.9 ± 9 min vs. 41.6 ± 15 min). Individuals with stroke had less fatigue-related changes in muscle contractile properties and women with stroke differed in their muscle activation strategy during the fatiguing contractions. Conclusions: Men and women fatigue differently post-stroke and this may be due to the way they neurally activate muscle groups. View Full-Text
Keywords: fatigability; muscle fatigue; knee extensors; sex differences; chronic stroke; gender fatigability; muscle fatigue; knee extensors; sex differences; chronic stroke; gender
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Kirking, M.; Berrios Barillas, R.; Nelson, P.A.; Hunter, S.K.; Hyngstrom, A. Sex Differences in Neuromuscular Fatigability of the Knee Extensors Post-Stroke. Brain Sci. 2017, 7, 8.

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