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Brain Sci. 2016, 6(2), 17; doi:10.3390/brainsci6020017

Parkinson’s Disease: Assay of Phosphorylated α-Synuclein in Skin Biopsy for Early Diagnosis and Association with Melanoma

Department of Neurology, Kansas University Medical Center, Kansas City, 3901, Rainbow Boulevard, Kansas City, KS 66160, USA
Academic Editor: Balapal S. Basavarajappa
Received: 30 March 2016 / Revised: 19 May 2016 / Accepted: 24 May 2016 / Published: 26 May 2016
View Full-Text   |   Download PDF [550 KB, uploaded 26 May 2016]   |  

Abstract

Parkinson’s disease (PD) is a degenerative disorder of the central nervous system, in which a small naturally unfolded protein α-synuclein plays an essential role. α-Synuclein belongs to a synuclein family comprising three members: α, β, and γ-synucleins associated with neurodegenerative and neoplastic diseases and involved in development. Several studies revealed that α-synuclein is present not only in the brain, but also in the skin and other peripheral tissues. This finding open a new approach to PD diagnosis based on the assay of α-synuclein from a biological sample of a living patient. Furthermore, PD is associated with an increased risk of skin melanoma. An important posttranslational modification of α-synuclein is phosphorylation at serine-129, which may convert the protein into pathological species both in PD and melanoma. Thus, analysis of phosphorylated α-synuclein might be an important diagnostic test for both diseases providing additional information about the mechanism of pathology. View Full-Text
Keywords: Parkinson’s disease; neurodegeneration; melanoma; synuclein; phosphorylation; diagnosis Parkinson’s disease; neurodegeneration; melanoma; synuclein; phosphorylation; diagnosis
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Surguchov, A. Parkinson’s Disease: Assay of Phosphorylated α-Synuclein in Skin Biopsy for Early Diagnosis and Association with Melanoma. Brain Sci. 2016, 6, 17.

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