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Brain Sci. 2016, 6(2), 11; doi:10.3390/brainsci6020011

Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These EffectsAn Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies

Department of Anesthesiology, New Jersey Medical School, Rutgers University, Newark, NJ 07107, USA
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Academic Editor: Balapal S. Basavarajappa
Received: 29 October 2015 / Revised: 8 March 2016 / Accepted: 11 March 2016 / Published: 28 March 2016
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Abstract

In the past twenty years, evidence of neurotoxicity in the developing brain in animal studies from exposure to several general anesthetics has been accumulating. Propofol, a commonly used general anesthetic medication, administered during synaptogenesis, may trigger widespread apoptotic neurodegeneration in the developing brain and long-term neurobehavioral disturbances in both rodents and non-human primates. Despite the growing evidence of the potential neurotoxicity of different anesthetic agents in animal studies, there is no concrete evidence that humans may be similarly affected. However, given the growing evidence of the neurotoxic effects of anesthetics in laboratory studies, it is prudent to further investigate the mechanisms causing these effects and potential ways to mitigate them. Here, we review multiple studies that investigate the effects of in utero propofol exposure and the developmental agents that may modify these deleterious effects. View Full-Text
Keywords: propofol; neurotoxicity; in utero; apoptosis propofol; neurotoxicity; in utero; apoptosis
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xiong, M.; Zhang, L.; Li, J.; Eloy, J.; Ye, J.H.; Bekker, A. Propofol-Induced Neurotoxicity in the Fetal Animal Brain and Developments in Modifying These EffectsAn Updated Review of Propofol Fetal Exposure in Laboratory Animal Studies. Brain Sci. 2016, 6, 11.

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