Next Article in Journal
Defining the Parameters of Incidental Learning on a Serial Reaction Time (SRT) Task: Do Conscious Rules Apply?
Next Article in Special Issue
Long-Term Consequences of Developmental Alcohol Exposure on Brain Structure and Function: Therapeutic Benefits of Physical Activity
Previous Article in Journal / Special Issue
On Aerobic Exercise and Behavioral and Neural Plasticity
Brain Sci. 2012, 2(4), 745-768; doi:10.3390/brainsci2040745

Wnt Signaling in Neurogenesis during Aging and Physical Activity

*  and
Department of Biological Sciences, California State University, 5151 State University Drive, Los Angeles, CA 90032, USA
* Author to whom correspondence should be addressed.
Received: 30 September 2012 / Revised: 27 November 2012 / Accepted: 10 December 2012 / Published: 14 December 2012
(This article belongs to the Special Issue Exercise and Brain Function)
View Full-Text   |   Download PDF [956 KB, uploaded 14 December 2012]   |   Browse Figures


Over the past decade, much progress has been made regarding our understanding of neurogenesis in both young and old animals and where it occurs throughout the lifespan, although the growth of new neurons declines with increasing age. In addition, physical activity can reverse this age-dependent decline in neurogenesis. Highly correlated with this decline is the degree of inter and intracellular Wnt signaling, the molecular mechanisms of which have only recently started to be elucidated. So far, most of what we know about intracellular signaling during/following exercise centers around the CREB/CRE initiated transcriptional events. Relatively little is known, however, about how aging and physical activity affect the Wnt signaling pathway. Herein, we briefly review the salient features of neurogenesis in young and then in old adult animals. Then, we discuss Wnt signaling and review the very few in vitro and in vivo studies that have examined the Wnt signaling pathways in aging and physical activity.
Keywords: Wnt; running; exercise; neurogenesis; aging; hippocampus Wnt; running; exercise; neurogenesis; aging; hippocampus
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Chen, M.; Do, H. Wnt Signaling in Neurogenesis during Aging and Physical Activity. Brain Sci. 2012, 2, 745-768.

View more citation formats

Related Articles

Article Metrics


[Return to top]
Brain Sci. EISSN 2076-3425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert