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Appl. Sci. 2018, 8(9), 1616; https://doi.org/10.3390/app8091616

Numerical Investigation of the Effects of Red Blood Cell Cytoplasmic Viscosity Contrasts on Single Cell and Bulk Transport Behaviour

1
Computational Science Lab, Faculty of Science, Institute for Informatics, University of Amsterdam, 1012 Amsterdam, The Netherlands
2
Department of Hydrodynamic Systems, Budapest University of Technology and Economics, 1111 Budapest, Hungary
3
ITMO University, 197101 Saint Petersburg, Russia
*
Author to whom correspondence should be addressed.
Received: 30 July 2018 / Revised: 5 September 2018 / Accepted: 7 September 2018 / Published: 11 September 2018
(This article belongs to the Special Issue Development and Applications of Kinetic Solvers for Complex Flows)
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Abstract

In-silico cellular models of blood are invaluable to gain understanding about the many interesting properties that blood exhibits. However, numerical investigations that focus on the effects of cytoplasmic viscosity in these models are not very prevalent. We present a parallelised method to implement cytoplasmic viscosity for HemoCell, an open-source cellular model based on immersed boundary lattice Boltzmann methods, using an efficient ray-casting algorithm. The effects of the implementation are investigated with single-cell simulations focusing on the deformation in shear flow, the migration due to wall induced lift forces, the characteristic response time in periodic stretching and pair collisions between red blood cells and platelets. Collective transport phenomena are also investigated in many-cell simulations in a pressure driven channel flow. The simulations indicate that the addition of a viscosity contrast between internal and external fluids significantly affects the deformability of a red blood cell, which is most pronounced during very short time-scale events. Therefore, modelling the cytoplasmic viscosity contrast is important in scenarios with high velocity deformation, typically high shear rate flows. View Full-Text
Keywords: cellular blood flow; cytoplasmic viscosity contrast; red blood cells; cell mechanics; immersed boundary method; lattice Boltzmann method cellular blood flow; cytoplasmic viscosity contrast; red blood cells; cell mechanics; immersed boundary method; lattice Boltzmann method
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de Haan, M.; Zavodszky, G.; Azizi, V.; Hoekstra, A.G. Numerical Investigation of the Effects of Red Blood Cell Cytoplasmic Viscosity Contrasts on Single Cell and Bulk Transport Behaviour. Appl. Sci. 2018, 8, 1616.

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