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Appl. Sci. 2018, 8(9), 1579; https://doi.org/10.3390/app8091579

Comparative Study with 89Y-foil and 89Y-pressed Targets for the Production of 89Zr

1
Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, 12e Avenue Nord, Sherbrooke, QC J1H 5N4, Canada
2
Sherbrooke Molecular Imaging Centre (CIMS) of the CRCHUS, 3001, 12e Avenue Nord, Sherbrooke, QC J1H 5N4, Canada
The results have been presented orally at the Society of Nuclear Medicine and Molecular Imaging 2017 Annual Meeting (June 2017, Denver, CO, USA).
*
Author to whom correspondence should be addressed.
Received: 16 August 2018 / Revised: 1 September 2018 / Accepted: 4 September 2018 / Published: 7 September 2018
(This article belongs to the Section Chemistry)
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Abstract

Zirconium-89 (89Zr, t1/2 = 3.27 days) owns great potential in nuclear medicine, being extensively used in the labelling of antibodies and nanoparticules. 89Zr can be produced by cyclotron via an 89Y(p,n)89Zr reaction while using an 89Y-foil target. In this study, we investigated for the first time the use of 89Y-pressed target for the preparation of 89Zr-oxalate via a (p,n) reaction. We performed comparative studies with an 89Y-foil target mounted on custom-made target supports. A new automated cassette-based purification module was used to facilitate the purification and the fractionation of 89Zr-oxalate. The effective molar activity (EMA) was calculated for both approaches via titration with deferoxamine (DFO). The radionuclidic purity was determined by gamma-ray spectroscopy and the metal impurities were quantified by ICP-MS on the resulting 89Zr-oxalate solution. The cassette-based purification process leading to fractionation is simple, efficient, and provides very high EMA of 89Zr-oxalate. The total recovered activity was 81 ± 4% for both approaches. The highest EMA was found at 13.3 MeV and 25 μA for 0.25-mm thick 89Y-foil. Similar and optimal production yields were obtained at 15 MeV and 40 μA while using 0.50-mm thick 89Y-foil and pressed targets. Metallic impurities concentration was below the general limit of 10 ppm for heavy metals in the US and Ph.Eur for both 89Y-foil and pressed targets. Overall, these results show that the irradiation of 89Y-pressed targets is a very effective process, offering an alternative method for 89Zr production. View Full-Text
Keywords: 89Y-pressed target; 89Y-foil; custom-made target supports; proton irradiation; automated cassette-based module; 89Zr-oxalate fractionation; effective molar activity 89Y-pressed target; 89Y-foil; custom-made target supports; proton irradiation; automated cassette-based module; 89Zr-oxalate fractionation; effective molar activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Alnahwi, A.H.; Tremblay, S.; Guérin, B. Comparative Study with 89Y-foil and 89Y-pressed Targets for the Production of 89Zr . Appl. Sci. 2018, 8, 1579.

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