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Appl. Sci. 2017, 7(7), 687; doi:10.3390/app7070687

Can OCT Angiography Be Made a Quantitative Blood Measurement Tool?

1
Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, USA
2
Department of Ophthalmology and Vision Science, School of Medicine, University of California Davis, Sacramento, CA 95817, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Michael Pircher
Received: 11 May 2017 / Revised: 19 June 2017 / Accepted: 19 June 2017 / Published: 4 July 2017
(This article belongs to the Special Issue Development and Application of Optical Coherence Tomography (OCT))
View Full-Text   |   Download PDF [6879 KB, uploaded 7 July 2017]   |  

Abstract

Optical Coherence Tomography Angiography (OCTA) refers to a powerful class of OCT scanning protocols and algorithms that selectively enhance the imaging of blood vessel lumens, based mainly on the motion and scattering of red blood cells (RBCs). Though OCTA is widely used in clinical and basic science applications for visualization of perfused blood vessels, OCTA is still primarily a qualitative tool. However, more quantitative hemodynamic information would better delineate disease mechanisms, and potentially improve the sensitivity for detecting early stages of disease. Here, we take a broader view of OCTA in the context of microvascular hemodynamics and light scattering. Paying particular attention to the unique challenges presented by capillaries versus larger supplying and draining vessels, we critically assess opportunities and challenges in making OCTA a quantitative tool. View Full-Text
Keywords: optical coherence tomography; angiography; scattering; red blood cells; rheology; imaging; hemodynamics; blood flow optical coherence tomography; angiography; scattering; red blood cells; rheology; imaging; hemodynamics; blood flow
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zhu, J.; Merkle, C.W.; Bernucci, M.T.; Chong, S.P.; Srinivasan, V.J. Can OCT Angiography Be Made a Quantitative Blood Measurement Tool? Appl. Sci. 2017, 7, 687.

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