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Appl. Sci. 2017, 7(5), 484; doi:10.3390/app7050484

Numerical Simulation of Red Blood Cell-Induced Platelet Transport in Saccular Aneurysms

1
Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
2
Department of Mechanical and Nuclear Engineering, The Pennsylvania State University, State College, PA 16803, USA
3
Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115
4
U.S. Department of Energy, National Energy Technology Laboratory (NETL), Pittsburgh, PA 15236, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Fan-Gang Tseng
Received: 2 March 2017 / Revised: 3 May 2017 / Accepted: 4 May 2017 / Published: 6 May 2017
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Abstract

We present a numerical simulation of blood flow in two aneurysmal vessels. Using a multicomponent continuum approach, called mixture theory, the velocity fields and spatial distribution of the red blood cells (RBCs) and the plasma are predicted. Platelet migration is described by a convection-diffusion equation, coupled to the RBC concentration field. The model is applied to study a two-dimensional straight vessel and multiple two-dimensional aneurysm vessels with different neck sizes. The model accurately predicts the enrichment of the platelets near the wall in the straight vessel, agreeing with the experimental measurement quantitatively. The numerical results also show that the near-wall enrichment of the platelets in the parent vessel highly influences the platelet concentration within the aneurysm. The results also indicate that the platelet concentration within the aneurysm increases with Reynolds number and decreases with a smaller neck size. This might have significance on the formation of thrombus (blood clot) within the aneurysm, which in turn may have a protective effect on preventing ruptures. Based on the success with the problems studied, we believe the current model can be a useful tool for analyzing the blood flow and platelets transport within patient specific aneurysms in the future. View Full-Text
Keywords: blood flow; platelets transport; multiphase flow; RBCs; aneurysm; mixture theory; thrombosis blood flow; platelets transport; multiphase flow; RBCs; aneurysm; mixture theory; thrombosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Wu, W.-T.; Li, Y.; Aubry, N.; Massoudi, M.; Antaki, J.F. Numerical Simulation of Red Blood Cell-Induced Platelet Transport in Saccular Aneurysms. Appl. Sci. 2017, 7, 484.

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