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Appl. Sci. 2017, 7(4), 415; doi:10.3390/app7040415

Fusion of Intraoperative 3D B-mode and Contrast-Enhanced Ultrasound Data for Automatic Identification of Residual Brain Tumors

1
Telematics (CA), Engineering Division (DICIS), University of Guanajuato, Campus Irapuato-Salamanca, Carr. Salamanca-Valle km 3.5 + 1.8, Comunidad de Palo Blanco, Salamanca, Gto. 36885, Mexico
2
Department of Neurosurgery, University Hospital Leipzig, Leipzig 04103, Germany;
3
Innovation Center Computer Assisted Surgery (ICCAS), University of Leipzig, Leipzig 04103, Germany
4
Centro de Investigacion en Matematicas (CIMAT), A.C., Jalisco S/N, Col. Valenciana, Guanajuato, Gto. 36000, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Hideyuki Hasegawa
Received: 15 February 2017 / Revised: 11 April 2017 / Accepted: 17 April 2017 / Published: 19 April 2017
View Full-Text   |   Download PDF [2128 KB, uploaded 24 April 2017]   |  

Abstract

Intraoperative ultrasound (iUS) imaging is routinely performed to assist neurosurgeons during tumor surgery. In particular, the identification of the possible presence of residual tumors at the end of the intervention is crucial for the operation outcome. B-mode ultrasound remains the standard modality because it depicts brain structures well. However, tumorous tissue is hard to differentiate from resection cavity borders, blood and artifacts. On the other hand, contrast enhanced ultrasound (CEUS) highlights residuals of the tumor, but the interpretation of the image is complex. Therefore, an assistance system to support the identification of tumor remnants in the iUS data is needed. Our approach is based on image segmentation and data fusion techniques. It consists of combining relevant information, automatically extracted from both intraoperative B-mode and CEUS image data, according to decision rules that model the analysis process of neurosurgeons to interpret the iUS data. The method was tested on an image dataset of 23 patients suffering from glioblastoma. The detection rate of brain areas with tumor residuals reached by the algorithm was qualitatively and quantitatively compared with manual annotations provided by experts. The results showed that the assistance tool was able to successfully identify areas with suspicious tissue. View Full-Text
Keywords: assistance system; neurosurgery; operating room; glioblastoma assistance system; neurosurgery; operating room; glioblastoma
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MDPI and ACS Style

Ilunga-Mbuyamba, E.; Lindner, D.; Avina-Cervantes, J.G.; Arlt, F.; Rostro-Gonzalez, H.; Cruz-Aceves, I.; Chalopin, C. Fusion of Intraoperative 3D B-mode and Contrast-Enhanced Ultrasound Data for Automatic Identification of Residual Brain Tumors. Appl. Sci. 2017, 7, 415.

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