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Appl. Sci. 2017, 7(3), 237;

Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica

Faculty of Pharmacy, Grigore. T. Popa University of Medicine and Pharmacy, Iasi 700115, Romania
Faculty of Chemistry, Alexandru Ioan Cuza University of Iasi, Iasi 700560, Romania
Faculty of Chemical Engineering and Protection of the Environment, Gheorghe Asachi Technical University of Iasi, Iasi 700050, Romania
Petru Poni Institute of Macromolecular Chemistry, Iasi 700487, Romania
Faculty of Mathematics, Alexandru Ioan Cuza University of Iasi, 11 Blvd. Carol I, Iasi 700506, Romania
Authors to whom correspondence should be addressed.
Academic Editors: Yurii K. Gun’ko and Hidenori Otsuka
Received: 14 November 2016 / Revised: 26 January 2017 / Accepted: 27 February 2017 / Published: 2 March 2017
(This article belongs to the Section Nanotechnology and Applied Nanosciences)
View Full-Text   |   Download PDF [4690 KB, uploaded 2 March 2017]   |  


Magnolol (MG) is a small-molecule neolignan polyphenolic compound isolated from the genus Magnolia. The anti-inflammatory, anti-oxidative, anti-diabetic, anti-tumorgenic, anti-neurodegenerative, anti-depressant and anti-microbial properties of MG are well documented in recent literature. These fascinating multiple biological activities of MG encourage research about the development of new delivery and administration approaches able to maximize its potential benefits. This study describes the amino-functionalization of the SBA-15 (Santa Barbara Amorphous) mesoporous matrix by post-synthesis grafting using APTES (3-aminopropyltriethoxysilane) and the characterization of amino-functionalized mesoporous silica SBA-15 loaded with MG in order to achieve modified drug delivery systems. The amino-functionalization of silica SBA-15 was carried out by grafting by refluxing in dry toluene. The powders obtained were characterized texturally by Brunauer-Emmett-Teller (BET) surface area analysis measurements and morphologically by scanning electron microscopy. MG loading degree in the nanoporous matrix was determined by the HPLC method at λ = 290 nm. Results showed that by grafting the amino groups in the silica SBA-15, we obtained amino-functionalized silica SBA-15 with an ordered structure, with specific surfaces and pore sizes that differ from the original matrix, which was reflected in the amount of MG immobilized and release kinetics profile. View Full-Text
Keywords: magnolol; amino-functionalized; mesoporous silica; prolonged drug; delivery system magnolol; amino-functionalized; mesoporous silica; prolonged drug; delivery system

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Stefanache, A.; Ignat, M.; Peptu, C.A.; Diaconu, A.; Stoleriu, I.; Ochiuz, L. Development of a Prolonged-Release Drug Delivery System with Magnolol Loaded in Amino-Functionalized Mesoporous Silica. Appl. Sci. 2017, 7, 237.

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