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Appl. Sci. 2017, 7(2), 113; doi:10.3390/app7020113

Importance of Physical and Physiological Parameters in Simulated Particle Transport in the Alveolar Zone of the Human Lung

1
Vocational School of Higher Education, Atatürk University, Erzurum 25240, Turkey
2
Elm_o_fan University College of Science and Technology, Urmia 57159, Iran
3
Department of Mechanical Engineering, Atatürk University, Erzurum 25240, Turkey
4
Faculty of Engineering and Applied Science, University of Ontario Institute of Technology, 2000 Simcoe Street North, Oshawa, ON L1H 7K4, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Serafim Kalliadasis
Received: 14 September 2016 / Revised: 11 January 2017 / Accepted: 17 January 2017 / Published: 24 January 2017
View Full-Text   |   Download PDF [6756 KB, uploaded 24 January 2017]   |  

Abstract

The trajectory and deposition efficiency of micron-sized (1–5 µm) particles, inhaled into the pulmonary system, are accurately determined with the aid of a newly developed model and modified simulation techniques. This alveolar model, which has a simple but physiologically appropriate geometry, and the utilized fluid structure interaction (FSI) methods permit the precise simulation of tissue wall deformation and particle fluid interactions. The relation between tissue movement and airflow in the alveolated duct is solved by a two-way fluid structure interaction simulation technique, using ANSYS Workbench (Release 16.0, ANSYS INC., Pittsburgh, PA, USA, 2015). The dynamic transport of particles and their deposition are investigated as a function of aerodynamic particle size, tissue visco-elasticity, tidal breathing period, gravity orientation and particle–fluid interactions. It is found that the fluid flows and streamlines differ between the present flexible model and rigid models, and the two-way coupling particle trajectories vary relative to one-way particle coupling. In addition, the results indicate that modelling the two-way coupling particle system is important because the two-way discrete phase method (DPM) approach despite its complexity provides more extensive particle interactions and is more reliable than transport results from the one-way DPM approach. The substantial difference between the results of the two approaches is likely due to particle–fluid interactions, which re-suspend the sediment particles in the airway stream and hence pass from the current generation. View Full-Text
Keywords: alveolar; two-way fluid structure interaction; tissue mechanics; particle fluid interaction; particle deposition alveolar; two-way fluid structure interaction; tissue mechanics; particle fluid interaction; particle deposition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ciloglu, D.; Athari, H.; Bolukbasi, A.; Rosen, M.A. Importance of Physical and Physiological Parameters in Simulated Particle Transport in the Alveolar Zone of the Human Lung. Appl. Sci. 2017, 7, 113.

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