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Appl. Sci. 2017, 7(1), 49; doi:10.3390/app7010049

FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol

1
Departamento de Física, Universidad Técnica Federico Santa María, Valparaíso 2340000, Chile
2
Centro del Desarrollo para la Nanociencia y Nanotecnología-CEDENNA, Universidad de Santiago de Chile, Santiago 8320000, Chile
3
Laboratorio de Inmunología de la Reproducción, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 8320000, Chile
4
Instituto de Quimica y Bioquímica, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile
5
Grupo Polímeros, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 8320000, Chile
*
Author to whom correspondence should be addressed.
Academic Editor: Jordi Puiggalí
Received: 16 September 2016 / Revised: 29 October 2016 / Accepted: 11 November 2016 / Published: 4 January 2017
(This article belongs to the Special Issue Biodegradable and Biocompatible Nanoparticles)
View Full-Text   |   Download PDF [1536 KB, uploaded 4 January 2017]   |  

Abstract

The aim of this study was to prepare a novel targeting drug delivery system for 2-Methoxyestradiol (2ME) in order to improve the clinical application of this antitumor drug. It is based in nanoparticles (NPs) of titanium dioxide (TiO2) coated with polyethylene glycol (PEG) and loaded with 2ME. A complete IR and Raman characterization have been made to confirm the formation of TiO2–PEG–2ME composite. Vibrational modes have been assigned for TiO2, PEG, and 2ME and functionalized TiO2–PEG and TiO2–PEG–2ME. The observed variation in peak position of FTIR and Raman of each for these composites has been elucidated in terms of intermolecular interactions between PEG–2ME and TiO2, obtaining step-by-step the modification processes that were attributed to the conjugation of PEG and 2ME to TiO2 NPs. Modifying TiO2 NPs with PEG loaded with the 2ME drug revealed that the titanium dioxide nanocarrier possesses an effective adsorption capability, and we discuss their potential application as a system of drug delivery. View Full-Text
Keywords: TiO2 NPs; drug delivery; 2-Methoxyestradiol; anticancer drug; TiO2-2ME NPs TiO2 NPs; drug delivery; 2-Methoxyestradiol; anticancer drug; TiO2-2ME NPs
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MDPI and ACS Style

León, A.; Reuquen, P.; Garín, C.; Segura, R.; Vargas, P.; Zapata, P.; Orihuela, P.A. FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol. Appl. Sci. 2017, 7, 49.

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