FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol
Departamento de Física, Universidad Técnica Federico Santa María, Valparaíso 2340000, Chile
Centro del Desarrollo para la Nanociencia y Nanotecnología-CEDENNA, Universidad de Santiago de Chile, Santiago 8320000, Chile
Laboratorio de Inmunología de la Reproducción, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 8320000, Chile
Instituto de Quimica y Bioquímica, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2340000, Chile
Grupo Polímeros, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago 8320000, Chile
Author to whom correspondence should be addressed.
Academic Editor: Jordi Puiggalí
Received: 16 September 2016 / Revised: 29 October 2016 / Accepted: 11 November 2016 / Published: 4 January 2017
The aim of this study was to prepare a novel targeting drug delivery system for 2-Methoxyestradiol (2ME) in order to improve the clinical application of this antitumor drug. It is based in nanoparticles (NPs) of titanium dioxide (TiO
) coated with polyethylene glycol (PEG) and loaded with 2ME. A complete IR and Raman characterization have been made to confirm the formation of TiO
–PEG–2ME composite. Vibrational modes have been assigned for TiO
, PEG, and 2ME and functionalized TiO
–PEG and TiO
–PEG–2ME. The observed variation in peak position of FTIR and Raman of each for these composites has been elucidated in terms of intermolecular interactions between PEG–2ME and TiO
, obtaining step-by-step the modification processes that were attributed to the conjugation of PEG and 2ME to TiO
NPs. Modifying TiO
NPs with PEG loaded with the 2ME drug revealed that the titanium dioxide nanocarrier possesses an effective adsorption capability, and we discuss their potential application as a system of drug delivery.
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León, A.; Reuquen, P.; Garín, C.; Segura, R.; Vargas, P.; Zapata, P.; Orihuela, P.A. FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol. Appl. Sci. 2017, 7, 49.
León A, Reuquen P, Garín C, Segura R, Vargas P, Zapata P, Orihuela PA. FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol. Applied Sciences. 2017; 7(1):49.
León, Andrea; Reuquen, Patricia; Garín, Carolina; Segura, Rodrigo; Vargas, Patricio; Zapata, Paula; Orihuela, Pedro A. 2017. "FTIR and Raman Characterization of TiO2 Nanoparticles Coated with Polyethylene Glycol as Carrier for 2-Methoxyestradiol." Appl. Sci. 7, no. 1: 49.
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