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Appl. Sci. 2016, 6(12), 431; doi:10.3390/app6120431

Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions

1
Department of Chemistry, College of Sciences, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia
2
Department of Physics, College of Sciences, Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia
*
Author to whom correspondence should be addressed.
Academic Editor: Rajender S. Varma
Received: 4 November 2016 / Revised: 3 December 2016 / Accepted: 7 December 2016 / Published: 14 December 2016
(This article belongs to the Section Chemistry)
View Full-Text   |   Download PDF [384 KB, uploaded 14 December 2016]   |  

Abstract

A simple, green, and efficient approach was used to synthesize 3,4-dihydropyrimidines derivatives. We showed that the application of the planetary ball milling method with a ball-to-reagent weight ratio of 8 for the Biginelli reaction provides 3,4-dihydropyrimidines derivatives with excellent yields (>98%) in a short reaction time from the one-pot, three-component condensation of aldehydes, ethyl acetoacetate, and urea (or thiourea). View Full-Text
Keywords: Biginelli reaction; ball milling; catalyst-free; solvent-free; dihydropyrimine derivatives Biginelli reaction; ball milling; catalyst-free; solvent-free; dihydropyrimine derivatives
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Ould M’hamed, M.; Alshammari, A.G.; Lemine, O.M. Green High-Yielding One-Pot Approach to Biginelli Reaction under Catalyst-Free and Solvent-Free Ball Milling Conditions. Appl. Sci. 2016, 6, 431.

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